The role of TLC in investigation of diastereomeric salt formation by a group of pipecoloxylidides

Katalin Nemák, E. Fogassy, A. Bényei, I. Hermecz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We have investigated resolution of the enantiomers of each member of a group of five pipecoloxylidides. A standard TLC method was used for testing the chemical purity of the diastereomeric salts of the pipecoloxylidides. Evaluation of the chromatograms also revealed properties of the materials related to those which affected their behavior during optical resolution via diastereomeric salt formation. In further steps we used TLC not only for quantitative analysis but also for qualitative tests. After several laboratory trials we developed a new, efficient TLC method which has been used to investigate the diastereomeric salt-forming behavior of the compounds.

Original languageEnglish
Pages (from-to)125-128
Number of pages4
JournalJournal of Planar Chromatography - Modern TLC
Volume21
Issue number2
DOIs
Publication statusPublished - Apr 2008

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Salts
Enantiomers
Testing
Chemical analysis

Keywords

  • Diastereomeric salt formation
  • Pipecoloxylidides
  • Resolution of enantiomers
  • Selection of resolving agents
  • Standardized TLC

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

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