The role of thromboxane A2 in complement activation-related pseudoallergy

Tamás Gyula Fülöp, Josbert M. Metselaar, Gert Storm, J. Szebeni

Research output: Contribution to journalReview article

Abstract

Complement activation-related pseudoallergy (CARPA) is a hypersensitivity reaction occurring upon intravenous administration of numerous liposomal therapeutics, other nonbiological complex drugs and biologicals. It has a complex molecular and cellular mechanism that involves the production, actions and interactions of numerous vasoactive mediators in blood, including thromboxane A2 (TXA2). This short review focuses on the latter eicosanoid: Its role in CARPA, effects underlying some of the symptoms and experimental evidence for its rate-limiting role in pulmonary hypertension in pigs. Animal experiments and recent clinical observations suggest that the cyclooxygenase blocker indomethacin may represent an effective new approach to prevent liposome-induced CARPA, lending clinical relevance to better understand the involvement of TXA2 and other eicosanoids in this adverse immune effect.

Original languageEnglish
Pages (from-to)59-67
Number of pages9
JournalEuropean Journal of Nanomedicine
Volume9
Issue number2
DOIs
Publication statusPublished - Apr 1 2017

Fingerprint

Thromboxane A2
Complement Activation
complement
Eicosanoids
Chemical activation
activation
hypertension
swine
Liposomes
Prostaglandin-Endoperoxide Synthases
Pulmonary Hypertension
Indomethacin
Intravenous Administration
blood
animals
Hypersensitivity
Animals
drugs
Blood
Swine

Keywords

  • adverse drug reactions
  • allergy
  • anaphylatoxins
  • anaphylaxis
  • animal models
  • hemodynamic changes
  • hypersensitivity reactions
  • immune toxicity
  • pseudoallergy

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Physical and Theoretical Chemistry

Cite this

The role of thromboxane A2 in complement activation-related pseudoallergy. / Fülöp, Tamás Gyula; Metselaar, Josbert M.; Storm, Gert; Szebeni, J.

In: European Journal of Nanomedicine, Vol. 9, No. 2, 01.04.2017, p. 59-67.

Research output: Contribution to journalReview article

Fülöp, Tamás Gyula ; Metselaar, Josbert M. ; Storm, Gert ; Szebeni, J. / The role of thromboxane A2 in complement activation-related pseudoallergy. In: European Journal of Nanomedicine. 2017 ; Vol. 9, No. 2. pp. 59-67.
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