The role of the transient outward current in action potential repolarization: A simulation study

Beatriz Carbonel, Lázló Virág, Norbert Jost, András Varró, Chema Ferrero

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The potassium transient outward current (Ito) is activeonly during the early plateau of the action potential (AP) and, therefore, its role in governing APD is controversial. The goal of this work is to characterize Ito from patchclamp experiments in canine ventricular epicardial cells and demonstrate its influence in cardiac restitution using an AP mathematical model. Data from our experiments has been used to define a new mathematical model for Ito, which has been then inserted in the Decker et al. model for canine epicardial AP, substituting the original formulation of Ito. The new model predicts an increase in action potential duration (APD) when Ito is blocked, in accordance with recent experimental evidence. Inspection of the ionic currents in the simulations show that the blockade of Ito may indirectly affect other plateau ionic currents like L-type Calcium current (ICaL) and the rapid component of the rectifier potassium current (IKr), producing an increment in the APD. These novel findings emphasize the importance of I to in repolarization and suggest a potential role of Ito blockade in arrhythmogenesis.

Original languageEnglish
Title of host publicationComputing in Cardiology 2010, CinC 2010
Pages657-660
Number of pages4
Publication statusPublished - Dec 1 2010
EventComputing in Cardiology 2010, CinC 2010 - Belfast, United Kingdom
Duration: Sep 26 2010Sep 29 2010

Publication series

NameComputing in Cardiology
Volume37
ISSN (Print)2325-8861
ISSN (Electronic)2325-887X

Other

OtherComputing in Cardiology 2010, CinC 2010
CountryUnited Kingdom
CityBelfast
Period9/26/109/29/10

ASJC Scopus subject areas

  • Computer Science(all)
  • Cardiology and Cardiovascular Medicine

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    Carbonel, B., Virág, L., Jost, N., Varró, A., & Ferrero, C. (2010). The role of the transient outward current in action potential repolarization: A simulation study. In Computing in Cardiology 2010, CinC 2010 (pp. 657-660). [5738058] (Computing in Cardiology; Vol. 37).