The role of the bone marrow derived mesenchymal stem cells in colonic epithelial regeneration

Gábor Valcz, Tibor Krenács, Ferenc Sipos, Katalin Leiszter, Kinga Tóth, Zsófia Balogh, Annamária Csizmadia, Györgyi Műzes, Béla Molnár, Zsolt Tulassay

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Bone marrow derived mesenchymal stem cells (BM-MSCs) take part in the colonic mucosal regeneration. They are multipotent cells, which can be identified with both negative (i.e. CD13, CD 14, CD45, c-Kit, major histocompatibility complex /MHC class I and II) and positive (i.e. CD54 (ICAM1), CD133, CD146 (MCAM), CD166, Flk-1, Sca-1, Thy-1, stage-specific antigen I /SSEA-I and Musashi-1, HLA class I) markers. These cells can repopulate the gastrointestinal mucosa as they may differentiate into stromal- (i.e. myofi-broblast) or epithelial-like (Paneth-, epithel-, goblet or enteroendocrin) cells without proliferation. During the mesenchymal to epithelial transition (MET) stem cells enter the epithelial layer and take up epithelial cell-like properties. Rarely BM-MSCs may retain their stem cell characteristics and are capable of producing progeny. The isolated lymphoid aggregates may serve as a platform from where BM-MSCs migrate to the nearby crypts as mediated by several chemoattractant proteins, which are expressed in injured tissue. The number of BM-MSCs is influenced by the degree of inflammation. In this review we summarize the current information about the role of BM-MSCs in the repair progress of injured colonic epithelium and their potential clinical applications.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalPathology and Oncology Research
Volume17
Issue number1
DOIs
Publication statusPublished - Mar 2011

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Keywords

  • Isolated lymphoid aggregates
  • Mesenchymal stem cells
  • Mesenchymal-epithelial transition
  • Mucosal regeneration

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

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