The role of the AT1 angiotensin receptor in cardiac hypertrophy: Angiotensin II receptor or stretch sensor?

László Hunyady, Gábor Turu

Research output: Contribution to journalShort survey

35 Citations (Scopus)

Abstract

Activation of the AT1 angiotensin receptor is a clinically important maladaptive response during cardiac hypertrophy. Autocrine and paracrine effects of locally generated angiotensin II, are believed to be the main mediators of these responses. However, a recent report has suggested that mechanical stress can activate AT1 receptors independently of angiotensin II generation. This finding, as well as recent studies on intracrine effects and the pharmacological consequences of receptor hetero- oligomerization, suggest that unexpected mechanisms could contribute to the role of the renin-angiotensin system during cardiac hypertrophy.

Original languageEnglish
Pages (from-to)405-408
Number of pages4
JournalTrends in Endocrinology and Metabolism
Volume15
Issue number9
DOIs
Publication statusPublished - Nov 2004

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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