The role of T-lymphocytes and cytokines in rheumatoid arthritis

J. S. Smolen, M. Tohidast-Akrad, A. Gal, M. Kunaver, G. Eberl, P. Zenz, A. Falus, G. Steiner

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

In this review the involvement of T cells, in addition to that of the monocyte/macrophage lineage, in the pathogenesis of rheumatoid arthritis is discussed. The evidence for the pathogenetic importance of T cells is based upon their state of activation in the synovial membrane and the cytokines produced. These cytokines can be detected in synovial fluids as well as in the synovial membrane by both immunohistochemistry and in situ hybridization. However, cytokine production can be detected only in a minor fraction of the T cells which contrasts the number of non-T cells observed to synthesize cytokines. Nevertheless, it can be assumed that the small amount of lymphokines is sufficient to activate a cytokine cascade derived from other cells. The cytokine profile secreted is indicative for a T cell response that primarily involves Th1-like cells.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalScandinavian Journal of Rheumatology
Volume25
Issue number1
Publication statusPublished - 1996

Fingerprint

Rheumatoid Arthritis
Cytokines
T-Lymphocytes
Synovial Membrane
Th1 Cells
Lymphokines
Synovial Fluid
In Situ Hybridization
Monocytes
Immunohistochemistry
Macrophages

Keywords

  • Cytokines
  • Gamma interferon
  • Osteoarthritis
  • Rheumatoid arthritis
  • T cells

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Smolen, J. S., Tohidast-Akrad, M., Gal, A., Kunaver, M., Eberl, G., Zenz, P., ... Steiner, G. (1996). The role of T-lymphocytes and cytokines in rheumatoid arthritis. Scandinavian Journal of Rheumatology, 25(1), 1-4.

The role of T-lymphocytes and cytokines in rheumatoid arthritis. / Smolen, J. S.; Tohidast-Akrad, M.; Gal, A.; Kunaver, M.; Eberl, G.; Zenz, P.; Falus, A.; Steiner, G.

In: Scandinavian Journal of Rheumatology, Vol. 25, No. 1, 1996, p. 1-4.

Research output: Contribution to journalArticle

Smolen, JS, Tohidast-Akrad, M, Gal, A, Kunaver, M, Eberl, G, Zenz, P, Falus, A & Steiner, G 1996, 'The role of T-lymphocytes and cytokines in rheumatoid arthritis', Scandinavian Journal of Rheumatology, vol. 25, no. 1, pp. 1-4.
Smolen JS, Tohidast-Akrad M, Gal A, Kunaver M, Eberl G, Zenz P et al. The role of T-lymphocytes and cytokines in rheumatoid arthritis. Scandinavian Journal of Rheumatology. 1996;25(1):1-4.
Smolen, J. S. ; Tohidast-Akrad, M. ; Gal, A. ; Kunaver, M. ; Eberl, G. ; Zenz, P. ; Falus, A. ; Steiner, G. / The role of T-lymphocytes and cytokines in rheumatoid arthritis. In: Scandinavian Journal of Rheumatology. 1996 ; Vol. 25, No. 1. pp. 1-4.
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