The role of surgery in the management of gestational trophoblastic neoplasia: The Hungarian experience

V. Fülöp, Iván Szigetvári, János Szepesi, György Végh, László Zsirai, Ross S. Berkowitz

Research output: Contribution to journalArticle

6 Citations (Scopus)


OBJECTIVE: To review the role of surgery in the management of gestational trophoblastic neoplasia (GTN) over the past 38 years in our national trophoblastic disease center. STUDY DESIGN: Between January 1, 1977, and December 31, 2014, 371 patients with low-risk GTN and 190 patients with high-risk GTN were treated with chemotherapy, surgical interventions, or both. The indications for hysterectomy included excision of large uterine tumor masses, uterine hemorrhage or sepsis, or a drug-resistant uterine focus. Metastases were excised due to the presence of drug-resistant foci or complications of disease such as hemorrhage. RESULTS: Over the period of 1977-2014 74 hysterectomies, 15 resections of vaginal metastases, 3 omentectomies, 13 adnexectomies, 9 lung resections, 1 nephrectomy, 1 lung resection and nephrectomy, and 2 craniotomies were performed among our patients. While hysterectomy was performed in 51 (26.8%) of 190 highrisk patients, hysterectomy was performed in only 23 (6.2%) of 371 low-risk patients (p

Original languageEnglish
Pages (from-to)197-204
Number of pages8
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number3
Publication statusPublished - Jun 1 2016



  • Chemotherapy
  • Choriocarcinoma
  • Drug therapy
  • Gestational trophoblastic disease
  • Gestational trophoblastic neoplasia
  • Gynecologic surgical procedures
  • Hysterectomy
  • Metastasis surgery

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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