The role of structural disorder in cell cycle regulation, related clinical proteomics, disease development and drug targeting

Agnes Tantos, L. Kalmár, Peter Tompa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Understanding the molecular mechanisms of the regulation of cell cycle is a central issue in molecular cell biology, due to its fundamental role in the existence of cells. The regulatory circuits that make decisions on when a cell should divide are very complex and particularly subtly balanced in eukaryotes, in which the harmony of many different cells in an organism is essential for life. Several hundred proteins are involved in these processes, and a great deal of studies attests that most of them have functionally relevant intrinsic structural disorder. Structural disorder imparts many functional advantages on these proteins, and we discuss it in detail that it is involved in all key steps from signaling through the cell membrane to regulating transcription of proteins that execute timely responses to an ever-changing environment.

Original languageEnglish
Pages (from-to)221-233
Number of pages13
JournalExpert Review of Proteomics
Volume12
Issue number3
DOIs
Publication statusPublished - Jun 1 2015

Fingerprint

Drug Delivery Systems
Proteomics
Cell Cycle
Cells
Cytology
Proteins
Molecular biology
Transcription
Cell membranes
Eukaryota
Cell Biology
Molecular Biology
Cell Membrane
Networks (circuits)

Keywords

  • cancer
  • cell-cycle
  • checkpoint
  • post-translational modification
  • protein disorder
  • signal transduction

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry

Cite this

The role of structural disorder in cell cycle regulation, related clinical proteomics, disease development and drug targeting. / Tantos, Agnes; Kalmár, L.; Tompa, Peter.

In: Expert Review of Proteomics, Vol. 12, No. 3, 01.06.2015, p. 221-233.

Research output: Contribution to journalArticle

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