A szteroidhormonok szerepe az oxidatív stressz elleni védekezésben

Translated title of the contribution: The role of steroid hormones in the protection against oxidative stress

G. Békési, J. Fehér

Research output: Contribution to journalReview article

Abstract

The incidence of vascular diseases increases in postmenopausal women. This negative trend seems to be controllable favourably by hormone replacement therapy (HRT). Based on the free radical mediated mechanism of atherogenesis the authors try to find the reasons for these observations on the basis of their and others' data. They consider the increase of activity and amount of neutrophil enzyme myeloperoxydase by certain steroid particulars one of the most important elements of the vasoprotective effect of HRT. This increase diminishes the production of superoxide anion by the inhibition of the NADPH-oxidase enzyme. The observation proved firstly by the authors, that the plasma levels of myeloperoxydase - and so the ability for the inhibition of superoxide anion production by neutrophils - decreases in elderly people, might explain the higher incidence of some free radical mediated illnesses in the elderly. The authors also give a short review of antioxidant effects of steroids in general.

Translated title of the contributionThe role of steroid hormones in the protection against oxidative stress
Original languageHungarian
Pages (from-to)100-106
Number of pages7
JournalLege Artis Medicinae
Volume11
Issue number2
Publication statusPublished - Apr 17 2001

ASJC Scopus subject areas

  • Medicine(all)

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