The role of stabilization centers in protein thermal stability

Csaba Magyar, M. Michael Gromiha, Zoltán Sávoly, István Simon

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The definition of stabilization centers was introduced almost two decades ago. They are centers of noncovalent long range interaction clusters, believed to have a role in maintaining the three-dimensional structure of proteins by preventing their decay due to their cooperative long range interactions. Here, this hypothesis is investigated from the viewpoint of thermal stability for the first time, using a large protein thermodynamics database. The positions of amino acids belonging to stabilization centers are correlated with available experimental thermodynamic data on protein thermal stability. Our analysis suggests that stabilization centers, especially solvent exposed ones, do contribute to the thermal stabilization of proteins.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalBiochemical and biophysical research communications
Volume471
Issue number1
DOIs
Publication statusPublished - Feb 26 2016

Keywords

  • Protein stability
  • Stability changing mutations
  • Stabilization centers
  • Thermal stability
  • Thermophiles

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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