The role of serum factors in the lymphocyte transformation test of children with acute leukaemia

T. Revesz, R. Szigeti, D. Schuler

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

PHA induced lymphocyte transformation tests were carried out in 14 children who were in full remission of acute lymphoblastic leukemia and in 12 controls. Stimulation was assessed on the basis of tritiated thymidine uptake. For an adequate testing of lymphocyte reactivity, dose response curves were established for each child. No significant difference could be observed in either the maximum response, or the shape of the curve, between the leukemic and the control groups. Supplementation of the culture medium with autologous plasma instead of AB serum did not result in any significant inhibition or stimulation of lymphocyte reactivity to PHA. The lymphocyte response of both leukemic and control children, however, was greatly reduced when sera from untreated leukemic children were used. Allogeneic sera drawn from patients in remission exerted little or no inhibitory effect, while that obtained in relapse was again more inhibitory. The observed effect was not due to cytotoxic antibodies, nor due to natural isoantibodies, but is thought to be a phenomenon closely connected with the active phase of malignant diseases. The exact nature of the agent is still far from being clarified at present.

Original languageEnglish
Title of host publicationACTA PAEDIAT.SCAND.
Pages715-720
Number of pages6
Volume63
Edition5
Publication statusPublished - 1974

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Lymphocyte Activation
Leukemia
Serum
Lymphocytes
Isoantibodies
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Thymidine
Culture Media
Recurrence
Control Groups
Antibodies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Revesz, T., Szigeti, R., & Schuler, D. (1974). The role of serum factors in the lymphocyte transformation test of children with acute leukaemia. In ACTA PAEDIAT.SCAND. (5 ed., Vol. 63, pp. 715-720)

The role of serum factors in the lymphocyte transformation test of children with acute leukaemia. / Revesz, T.; Szigeti, R.; Schuler, D.

ACTA PAEDIAT.SCAND.. Vol. 63 5. ed. 1974. p. 715-720.

Research output: Chapter in Book/Report/Conference proceedingChapter

Revesz, T, Szigeti, R & Schuler, D 1974, The role of serum factors in the lymphocyte transformation test of children with acute leukaemia. in ACTA PAEDIAT.SCAND.. 5 edn, vol. 63, pp. 715-720.
Revesz T, Szigeti R, Schuler D. The role of serum factors in the lymphocyte transformation test of children with acute leukaemia. In ACTA PAEDIAT.SCAND.. 5 ed. Vol. 63. 1974. p. 715-720
Revesz, T. ; Szigeti, R. ; Schuler, D. / The role of serum factors in the lymphocyte transformation test of children with acute leukaemia. ACTA PAEDIAT.SCAND.. Vol. 63 5. ed. 1974. pp. 715-720
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