A great deal of evidence has been presented concerning the role of the hypothalamic serotoninergic mechanism in the regulation of the pituitary-adrenal sytem. Physiological and pharmacological data indicate that hypothalamic serotonin represents an inhibitory mechanism in the function of the hypothalamo-pituitary-adrenal system during acute stress. Following acute stress, in the activation phase, a depletion of the serotonin occurs and in this way the hypothalamus is liberated from serotoninergic inhibition. As a consequence of the activation, the plasma corticosterone level increases and in the restoration phase the hypothalamic serotonin and the plasma corticosterone level return to normal. The previously increased glucocorticoid is attributed an important role in the restoration of the hypothalamic serotonin level. The data suggest that the serotonin plays an important role in the negative feedback action of the glucocorticoids.
|Number of pages||32|
|Publication status||Published - Jan 1 1976|
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