The role of renal prostaglandin E as a possible modulator of cyclic AMP production in nephrotic syndrome

S. Túri, Z. Havass, T. Bodrogi

Research output: Contribution to journalArticle

Abstract

Urinary prostaglandin E(PGE) and cyclic AMP (cAMP) excretions were studied by radioimmunoassay in children with nephrotic syndrome and in a control population. In cases with nephrotic syndrome there was a significant elevation in urinary PGE excretion and cAMP excretion was urinary osmolality (Uosm) and the ratio urine to plasma osmolality (Uosm/Posm); and a negative correlation between urinary cAMP excretion and urine volume. A negative correlation was observed between the values of PGE excretion and urinary cAMP. These data confirmed the role of PGE as a modulator of cAMP production, which was inhibited in the nephrotic syndrome.

Original languageEnglish
Pages (from-to)321-325
Number of pages5
JournalInternational Urology and Nephrology
Volume18
Issue number3
DOIs
Publication statusPublished - Sep 1986

Fingerprint

Nephrotic Syndrome
Prostaglandins E
Cyclic AMP
Kidney
Osmolar Concentration
Urine
Radioimmunoassay
Population

ASJC Scopus subject areas

  • Urology
  • Nephrology
  • Geriatrics and Gerontology

Cite this

The role of renal prostaglandin E as a possible modulator of cyclic AMP production in nephrotic syndrome. / Túri, S.; Havass, Z.; Bodrogi, T.

In: International Urology and Nephrology, Vol. 18, No. 3, 09.1986, p. 321-325.

Research output: Contribution to journalArticle

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