A sugárkezelés szerepe a gyermekkori medulloblastoma recidívájának és központi idegrendszeri áttéteinek megelozésében

Translated title of the contribution: The role of radiotherapy in the prevention of recurrence and central nervous system metastases in childhood medulloblastoma

Béla Kocsis, Lilla Pap, Gábor Székely, Nagy Z. Takácsi, György Németh

Research output: Contribution to journalArticle

Abstract

Purpose: To present the postoperative radiotherapy technique in children with medulloblastoma, and analyse the effectiveness of radiotherapy and the survival data. Materials and methods: 66 consecutive children (45 male and 21 female) received postoperative chemotherapy and radiotherapy between 1986 and 1998. The mean age was 8.3 years. The radiotherapy was performed with linear accelerator 9MV X-ray irradiation. The high risk patients received 36 Gy craniospinal irradiation, the low risk patients recived 30 Gy. The boost irradiation to the posterior fossa was 20 Gy in both patient groups. The patients received multi-drug chemotherapy immediately after the tumor resection. The radiotherapy started 6-8 weeks after the operation. Results: All 66 patients were evaluated. The mean follow-up time was 45.4 months. The chance of cure is higher at age 8 or more, and less favorable under age 8. After 60 months 68.6% of children under age 8 and 75.9% older than 8 are alive. 20 children (64.5%) are alive after radical tumorectomy and 11 died. The 5 year overall survival was 71%. Recurrence was observed in 23/66 cases, it was the most frequent cause of death. Local failure was in posterior fossa in 15 patients (68.2%). Conclusion: The radicality of operation had no significant influence to the overall survival. The tumor stage, age of patients, risk group and metastases are important prognostic factors.

Original languageHungarian
Pages (from-to)265-269
Number of pages5
JournalMagyar Onkologia
Volume44
Issue number4
Publication statusPublished - 2000

Fingerprint

Medulloblastoma
Radiotherapy
Central Nervous System
Neoplasm Metastasis
Recurrence
Survival
Craniospinal Irradiation
Drug Therapy
Particle Accelerators
Cause of Death
Neoplasms
X-Rays
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Oncology

Cite this

A sugárkezelés szerepe a gyermekkori medulloblastoma recidívájának és központi idegrendszeri áttéteinek megelozésében. / Kocsis, Béla; Pap, Lilla; Székely, Gábor; Takácsi, Nagy Z.; Németh, György.

In: Magyar Onkologia, Vol. 44, No. 4, 2000, p. 265-269.

Research output: Contribution to journalArticle

Kocsis, Béla ; Pap, Lilla ; Székely, Gábor ; Takácsi, Nagy Z. ; Németh, György. / A sugárkezelés szerepe a gyermekkori medulloblastoma recidívájának és központi idegrendszeri áttéteinek megelozésében. In: Magyar Onkologia. 2000 ; Vol. 44, No. 4. pp. 265-269.
@article{06da2fa426734368a6300dac6edaceca,
title = "A sug{\'a}rkezel{\'e}s szerepe a gyermekkori medulloblastoma recid{\'i}v{\'a}j{\'a}nak {\'e}s k{\"o}zponti idegrendszeri {\'a}tt{\'e}teinek megeloz{\'e}s{\'e}ben",
abstract = "Purpose: To present the postoperative radiotherapy technique in children with medulloblastoma, and analyse the effectiveness of radiotherapy and the survival data. Materials and methods: 66 consecutive children (45 male and 21 female) received postoperative chemotherapy and radiotherapy between 1986 and 1998. The mean age was 8.3 years. The radiotherapy was performed with linear accelerator 9MV X-ray irradiation. The high risk patients received 36 Gy craniospinal irradiation, the low risk patients recived 30 Gy. The boost irradiation to the posterior fossa was 20 Gy in both patient groups. The patients received multi-drug chemotherapy immediately after the tumor resection. The radiotherapy started 6-8 weeks after the operation. Results: All 66 patients were evaluated. The mean follow-up time was 45.4 months. The chance of cure is higher at age 8 or more, and less favorable under age 8. After 60 months 68.6{\%} of children under age 8 and 75.9{\%} older than 8 are alive. 20 children (64.5{\%}) are alive after radical tumorectomy and 11 died. The 5 year overall survival was 71{\%}. Recurrence was observed in 23/66 cases, it was the most frequent cause of death. Local failure was in posterior fossa in 15 patients (68.2{\%}). Conclusion: The radicality of operation had no significant influence to the overall survival. The tumor stage, age of patients, risk group and metastases are important prognostic factors.",
author = "B{\'e}la Kocsis and Lilla Pap and G{\'a}bor Sz{\'e}kely and Tak{\'a}csi, {Nagy Z.} and Gy{\"o}rgy N{\'e}meth",
year = "2000",
language = "Hungarian",
volume = "44",
pages = "265--269",
journal = "Magyar Onkologia",
issn = "0025-0244",
publisher = "Akademiai Kiado",
number = "4",

}

TY - JOUR

T1 - A sugárkezelés szerepe a gyermekkori medulloblastoma recidívájának és központi idegrendszeri áttéteinek megelozésében

AU - Kocsis, Béla

AU - Pap, Lilla

AU - Székely, Gábor

AU - Takácsi, Nagy Z.

AU - Németh, György

PY - 2000

Y1 - 2000

N2 - Purpose: To present the postoperative radiotherapy technique in children with medulloblastoma, and analyse the effectiveness of radiotherapy and the survival data. Materials and methods: 66 consecutive children (45 male and 21 female) received postoperative chemotherapy and radiotherapy between 1986 and 1998. The mean age was 8.3 years. The radiotherapy was performed with linear accelerator 9MV X-ray irradiation. The high risk patients received 36 Gy craniospinal irradiation, the low risk patients recived 30 Gy. The boost irradiation to the posterior fossa was 20 Gy in both patient groups. The patients received multi-drug chemotherapy immediately after the tumor resection. The radiotherapy started 6-8 weeks after the operation. Results: All 66 patients were evaluated. The mean follow-up time was 45.4 months. The chance of cure is higher at age 8 or more, and less favorable under age 8. After 60 months 68.6% of children under age 8 and 75.9% older than 8 are alive. 20 children (64.5%) are alive after radical tumorectomy and 11 died. The 5 year overall survival was 71%. Recurrence was observed in 23/66 cases, it was the most frequent cause of death. Local failure was in posterior fossa in 15 patients (68.2%). Conclusion: The radicality of operation had no significant influence to the overall survival. The tumor stage, age of patients, risk group and metastases are important prognostic factors.

AB - Purpose: To present the postoperative radiotherapy technique in children with medulloblastoma, and analyse the effectiveness of radiotherapy and the survival data. Materials and methods: 66 consecutive children (45 male and 21 female) received postoperative chemotherapy and radiotherapy between 1986 and 1998. The mean age was 8.3 years. The radiotherapy was performed with linear accelerator 9MV X-ray irradiation. The high risk patients received 36 Gy craniospinal irradiation, the low risk patients recived 30 Gy. The boost irradiation to the posterior fossa was 20 Gy in both patient groups. The patients received multi-drug chemotherapy immediately after the tumor resection. The radiotherapy started 6-8 weeks after the operation. Results: All 66 patients were evaluated. The mean follow-up time was 45.4 months. The chance of cure is higher at age 8 or more, and less favorable under age 8. After 60 months 68.6% of children under age 8 and 75.9% older than 8 are alive. 20 children (64.5%) are alive after radical tumorectomy and 11 died. The 5 year overall survival was 71%. Recurrence was observed in 23/66 cases, it was the most frequent cause of death. Local failure was in posterior fossa in 15 patients (68.2%). Conclusion: The radicality of operation had no significant influence to the overall survival. The tumor stage, age of patients, risk group and metastases are important prognostic factors.

UR - http://www.scopus.com/inward/record.url?scp=84875187636&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875187636&partnerID=8YFLogxK

M3 - Article

VL - 44

SP - 265

EP - 269

JO - Magyar Onkologia

JF - Magyar Onkologia

SN - 0025-0244

IS - 4

ER -