The role of proteasome in apoptosis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The proteasome is an abundant multicatalytic enzyme complex that provides the main pathway for degradation of intracellular proteins in eukaryotic cells. It was previously considered a humble garbage collector, performing housekeeping duties to remove misfolded or spent proteins. Recent findings also substantiate a pivotal role of the proteasome in the regulation of apoptosis. Polyubiquitin conjugation of key pro-and antiapoptotic molecules targets these proteins for proteasomal degradation. Moreover, regulators of apoptosis themselves seem to have an active part in the proteolytic inactivation of death executors.

Original languageEnglish
Title of host publicationApoptosis, Cell Signaling, and Human Diseases
PublisherHumana Press
Pages273-293
Number of pages21
Volume2
ISBN (Print)1588296776, 9781588296771
DOIs
Publication statusPublished - Dec 1 2007

Keywords

  • Ubiquitin
  • caspases
  • proteasome
  • proteolysis

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Low, P. (2007). The role of proteasome in apoptosis. In Apoptosis, Cell Signaling, and Human Diseases (Vol. 2, pp. 273-293). Humana Press. https://doi.org/10.1007/978-1-59745-199-4_13