The proteasome is an abundant multicatalytic enzyme complex that provides the main pathway for degradation of intracellular proteins in eukaryotic cells. It was previously considered a humble garbage collector, performing housekeeping duties to remove misfolded or spent proteins. Recent findings also substantiate a pivotal role of the proteasome in the regulation of apoptosis. Polyubiquitin conjugation of key pro-and antiapoptotic molecules targets these proteins for proteasomal degradation. Moreover, regulators of apoptosis themselves seem to have an active part in the proteolytic inactivation of death executors.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)