The role of proteasome in apoptosis

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The proteasome is an abundant multicatalytic enzyme complex that provides the main pathway for degradation of intracellular proteins in eukaryotic cells. It was previously considered a humble garbage collector, performing housekeeping duties to remove misfolded or spent proteins. Recent findings also substantiate a pivotal role of the proteasome in the regulation of apoptosis. Polyubiquitin conjugation of key pro-and antiapoptotic molecules targets these proteins for proteasomal degradation. Moreover, regulators of apoptosis themselves seem to have an active part in the proteolytic inactivation of death executors.

Original languageEnglish
Title of host publicationApoptosis, Cell Signaling, and Human Diseases
PublisherHumana Press
Pages273-293
Number of pages21
Volume2
ISBN (Print)1588296776, 9781588296771
DOIs
Publication statusPublished - 2007

Fingerprint

Proteasome Endopeptidase Complex
Proteolysis
Garbage
Polyubiquitin
Apoptosis
Housekeeping
Eukaryotic Cells
Degradation
Proteins
Enzymes
Molecules

Keywords

  • caspases
  • proteasome
  • proteolysis
  • Ubiquitin

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Lőw, P. (2007). The role of proteasome in apoptosis. In Apoptosis, Cell Signaling, and Human Diseases (Vol. 2, pp. 273-293). Humana Press. https://doi.org/10.1007/978-1-59745-199-4_13

The role of proteasome in apoptosis. / Lőw, P.

Apoptosis, Cell Signaling, and Human Diseases. Vol. 2 Humana Press, 2007. p. 273-293.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lőw, P 2007, The role of proteasome in apoptosis. in Apoptosis, Cell Signaling, and Human Diseases. vol. 2, Humana Press, pp. 273-293. https://doi.org/10.1007/978-1-59745-199-4_13
Lőw P. The role of proteasome in apoptosis. In Apoptosis, Cell Signaling, and Human Diseases. Vol. 2. Humana Press. 2007. p. 273-293 https://doi.org/10.1007/978-1-59745-199-4_13
Lőw, P. / The role of proteasome in apoptosis. Apoptosis, Cell Signaling, and Human Diseases. Vol. 2 Humana Press, 2007. pp. 273-293
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