The role of prostaglandins in several allergic and inflammatory processes

M. Kurti, M. Fekete, J. Borsy, G. Ambrus

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Effects of 3 prostaglandins: PGE1, dinoprostone (PGE2) and dinoprost (PGF(2α)) and 2 precursors (arachidonic and eicosatrienoic acids) on development of carrageenin edema, adjuvant arthritis, contact dermatitis and local anaphylaxis were investigated in rats and mice. In the presence of PGE1 and PGE2 the manifestations of allergic diseases were accentuated. This effect seemed to be indirect, based on liberation of histamine and serotonin from mast cells. The role of prostaglandins in the development of inflammatory processes is presumably of primary importance.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalPolish Journal of Pharmacology and Pharmacy
Volume26
Issue number1-2
Publication statusPublished - 1974

Fingerprint

Dinoprostone
Prostaglandins
Alprostadil
Arachidonic Acids
Experimental Arthritis
Dinoprost
Histamine Release
Carrageenan
Contact Dermatitis
Prostaglandins F
Anaphylaxis
Mast Cells
Edema
Serotonin

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

The role of prostaglandins in several allergic and inflammatory processes. / Kurti, M.; Fekete, M.; Borsy, J.; Ambrus, G.

In: Polish Journal of Pharmacology and Pharmacy, Vol. 26, No. 1-2, 1974, p. 109-115.

Research output: Contribution to journalArticle

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