Effects of 3 prostaglandins: PGE1, dinoprostone (PGE2) and dinoprost (PGF(2α)) and 2 precursors (arachidonic and eicosatrienoic acids) on development of carrageenin edema, adjuvant arthritis, contact dermatitis and local anaphylaxis were investigated in rats and mice. In the presence of PGE1 and PGE2 the manifestations of allergic diseases were accentuated. This effect seemed to be indirect, based on liberation of histamine and serotonin from mast cells. The role of prostaglandins in the development of inflammatory processes is presumably of primary importance.
|Number of pages||7|
|Journal||Polish journal of pharmacology and pharmacy|
|Publication status||Published - Jan 1 1974|
ASJC Scopus subject areas
- Pharmaceutical Science