The role of progesterone in implantation and trophoblast invasion

Melinda Halasz, J. Szekeres-Barthó

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

With its genomic and non-genomic actions, progesterone plays a role in preparing the endometrium for implantation and also in regulating trophoblast invasion and migration. The genomic actions of progesterone are mediated by the classical nuclear progesterone receptors, PR-A and PR-B. In addition to their genomic actions, nuclear progesterone receptors may also trigger rapid cytoplasmic signalling events. Membrane-bound progesterone receptors have been implicated in the rapid non-genomic actions of progesterone. Both genomic and extra-nuclear actions of progesterone are crucial for adequate decidualisation and implantation. Progesterone plays a role in establishing uterine receptivity by blocking the proliferative effect of oestrogen, by inducing genes that allow the endometrium to permit embryo attachment, and also acts as a negative regulator of trophoblast invasion by controlling matrix metalloproteinase (MMP) activity.

Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalJournal of Reproductive Immunology
Volume97
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint

Trophoblasts
Progesterone
Progesterone Receptors
Cytoplasmic and Nuclear Receptors
Endometrium
Matrix Metalloproteinases
Estrogens
Embryonic Structures
Membranes
Genes

Keywords

  • Invasion
  • Progesterone
  • Signalling
  • Trophoblast

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

The role of progesterone in implantation and trophoblast invasion. / Halasz, Melinda; Szekeres-Barthó, J.

In: Journal of Reproductive Immunology, Vol. 97, No. 1, 2013, p. 43-50.

Research output: Contribution to journalArticle

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