The role of PACAP in the control of circadian expression of clock genes in the chicken pineal gland

András D. Nagy, V. Csernus

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Several features of the molecular circadian oscillator of the chicken pineal gland show homology with those in the mammalian SCN. Studies have shown the effects of PACAP on the mammalian SCN, but its effects on the expression of clock genes in the avian pineal gland have not yet been demonstrated. Clock and Cry1 expression was analyzed in pineal glands of chicken embryos after exposure to PACAP-38 in vitro. PACAP reduced expression of both clock genes within 2 h. Ten hours after exposure, mRNA contents exceeded that of the controls. Our results support the hypothesis that the molecular clock machinery in the chicken pineal gland is also sensitive to PACAP.

Original languageEnglish
Pages (from-to)1767-1774
Number of pages8
JournalPeptides
Volume28
Issue number9
DOIs
Publication statusPublished - Sep 2007

Fingerprint

Pituitary Adenylate Cyclase-Activating Polypeptide
Circadian Clocks
Pineal Gland
Clocks
Chickens
Genes
Gene Expression
Machinery
Embryonic Structures
Messenger RNA

Keywords

  • Avian
  • Circadian
  • Clock
  • Cry1
  • Light
  • PACAP
  • Pineal gland

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

The role of PACAP in the control of circadian expression of clock genes in the chicken pineal gland. / Nagy, András D.; Csernus, V.

In: Peptides, Vol. 28, No. 9, 09.2007, p. 1767-1774.

Research output: Contribution to journalArticle

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