The role of oxytocin-dopamine interactions in cocaine-induced locomotor hyperactivity

G. L. Kovàcs, Z. Sarnyai, E. Babarczi, G. Szabó, G. Telegdy

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Cocaine is a widely used drug of abuse. One of the characteristic effects of this stimulant drug in the CNS of mice is the induction of motor hyperactivity. It was demonstrated that cocaine-induced motor hyperactivity could be blocked by pimozide, a dopamine receptor blocker, suggesting that dopamine was involved in cocaine-induced hyperactivity. Oxytocin, a neurohypophyseal neuropeptide, also partially antagonized cocaine-induced motor hyperactivity. Moreover, oxytocin antagonized the increased utilization of dopamine, elicited by cocaine in the nucleus accumbens. The data suggest that oxytocin may influence the behavioural effects of cocaine by affecting dopaminergic neurotransmission in some regions of the brain.

Original languageEnglish
Pages (from-to)365-368
Number of pages4
JournalNeuropharmacology
Volume29
Issue number4
DOIs
Publication statusPublished - Apr 1990

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Keywords

  • cocaine
  • dopamine utilization
  • hypermotility
  • oxytocin
  • pimozide

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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