Orális antidiabetikumok és angiotenzinkonvertáz- gátlók a 2-es típusú diabetes mellitus prevenciójában

Translated title of the contribution: The role of oral antidiabetic agents and ACE inhibitors in the prevention of type 2 diabetes mellitus

Research output: Contribution to journalArticle

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Abstract

Nowadays Type 2 diabetes is considered as a cardiovascular disease,. The cause of death among 80% of people with Type 2 diabetes is of cardiovascular origin, with the most common cause of death of myocardial infarction. Optimal solution would be the prevention of the disease and there are also some possibilities for intervention. The present paper summarises the role of antidiabetic agents and ACE inhibitors in the prevention of Type 2 diabetes mellitus. The incidence rate of Type 2 diabetes decreased by 36% using acarbose in the STOP NIDDM Trial and by 31% using metformin in the Diabetes Prevention Program. The rate of risk reduction regarding the incidence of Type 2 diabetes during the ALLHAT Study compared the subjects treated with thiazid diuretics among those treated with amlodipine was 25% by the end of the second year and 16% by the end of the fourth year, while the corresponding data for patients treated with lisinopril were 40% and 30%, respectively. The action of lisinopril on the better bioavailability of Insulin like growth factor I. (IGF-I) probably contributes to the beneficial effect of lisinopril on insulin sensitivity.

Original languageHungarian
Pages (from-to)753-758
Number of pages6
JournalLege Artis Medicinae
Volume14
Issue number11
Publication statusPublished - 2004

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Angiotensin-Converting Enzyme Inhibitors
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Lisinopril
Cause of Death
Acarbose
Amlodipine
Metformin
Incidence
Risk Reduction Behavior
Insulin-Like Growth Factor I
Diuretics
Biological Availability
Insulin Resistance
Cardiovascular Diseases
Myocardial Infarction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Orális antidiabetikumok és angiotenzinkonvertáz- gátlók a 2-es típusú diabetes mellitus prevenciójában. / Kempler, P.

In: Lege Artis Medicinae, Vol. 14, No. 11, 2004, p. 753-758.

Research output: Contribution to journalArticle

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