The role of NPY in the mediation of orexin-induced hypothermia

M. Jászberényi, E. Bujdosó, Edina Kiss, Imre Pataki, G. Telegdy

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The mediation of orexin-A-induced hypothermia was investigated. Different doses of orexin-A (140-560 pmol) were administered intracerebroventricularly (i.c.v.) to adult male rats, and the colon temperature was used as an index of the thermoregulatory action. Orexin-A decreased both the basal colon temperature and the lipopolysaccharide-induced fever and exhibited a bell-shaped dose-response curve. I.c.v. pretreatment with neuropeptide Y (NPY) antiserum 24 h before orexin administration significantly decreased the hypothermic effect of orexin-A. These data strengthen the hypothesis that this appetite-regulating peptide might also play a role in thermoregulation, and its hypothermic effect seems to be mediated at least partially by NPY.

Original languageEnglish
Pages (from-to)55-59
Number of pages5
JournalRegulatory Peptides
Volume104
Issue number1-3
DOIs
Publication statusPublished - Mar 15 2002

Fingerprint

Hypothermia
Induced Hypothermia
Neuropeptide Y
Colon
Temperature
Body Temperature Regulation
Appetite
Lipopolysaccharides
Rats
Immune Sera
Fever
Peptides
Orexins

Keywords

  • Lipopolysaccharide
  • Neuropeptide Y
  • Orexin-A
  • Thermoregulation

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

The role of NPY in the mediation of orexin-induced hypothermia. / Jászberényi, M.; Bujdosó, E.; Kiss, Edina; Pataki, Imre; Telegdy, G.

In: Regulatory Peptides, Vol. 104, No. 1-3, 15.03.2002, p. 55-59.

Research output: Contribution to journalArticle

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