The role of nitric oxide in the physiology and pathophysiology of the exocrine pancreas

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Significance: Nitric oxide (NO), a ubiquitous gaseous signaling molecule, contributes to both pancreatic physiology and pathophysiology. Recent Advances: The present review provides a general overview of NO synthesis, signaling, and function. Further, it specifically discusses NO metabolism and its effects in the exocrine pancreas and focuses on the role of NO in the pathogenesis of acute pancreatitis and pancreatic ischemia/reperfusion injury. Critical Issues: Unfortunately, the role of NO in pancreatic physiology and pathophysiology remains controversial in numerous areas. Many questions regarding the messenger molecule still remain unanswered. Future Directions: Probably the least is known about the downstream targets of NO, which need to be identified, especially at the molecular level.

Original languageEnglish
Pages (from-to)2723-2741
Number of pages19
JournalAntioxidants and Redox Signaling
Volume15
Issue number10
DOIs
Publication statusPublished - Nov 15 2011

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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