The role of NF-κB activation in the pathogenesis of acute pancreatitis

Z. Rakonczay, P. Hegyi, T. Takács, J. McCarroll, A. K. Saluja

Research output: Contribution to journalArticle

193 Citations (Scopus)

Abstract

Acute pancreatitis is an inflammatory disease of the pancreas which, in its most severe form, is associated with multi-organ failure and death. Recently, signalling molecules and pathways which are responsible for the initiation and progression of this disease have been under intense scrutiny. One important signalling molecule, nuclear factor κB (NF-κB), has been shown to play a critical role in the development of acute pancreatitis. NF-κB is a nuclear transcription factor responsible for regulating the transcription of a wide variety of genes involved in immunity and inflammation. Many of these genes have been implicated as central players in the development and progression of acute pancreatitis. This review discusses recent advances in the investigation of pancreatic and extrapancreatic (lungs, liver, monocytes and macrophages, and endothelial cells) NF-κB activation as it relates to acute pancreatitis.

Original languageEnglish
Pages (from-to)259-267
Number of pages9
JournalGut
Volume57
Issue number2
DOIs
Publication statusPublished - Feb 2008

Fingerprint

Pancreatitis
Genes
Disease Progression
Monocytes
Pancreas
Immunity
Transcription Factors
Endothelial Cells
Macrophages
Inflammation
Lung
Liver

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The role of NF-κB activation in the pathogenesis of acute pancreatitis. / Rakonczay, Z.; Hegyi, P.; Takács, T.; McCarroll, J.; Saluja, A. K.

In: Gut, Vol. 57, No. 2, 02.2008, p. 259-267.

Research output: Contribution to journalArticle

Rakonczay, Z. ; Hegyi, P. ; Takács, T. ; McCarroll, J. ; Saluja, A. K. / The role of NF-κB activation in the pathogenesis of acute pancreatitis. In: Gut. 2008 ; Vol. 57, No. 2. pp. 259-267.
@article{30f6d3ea4d854332b4a4f2180858b208,
title = "The role of NF-κB activation in the pathogenesis of acute pancreatitis",
abstract = "Acute pancreatitis is an inflammatory disease of the pancreas which, in its most severe form, is associated with multi-organ failure and death. Recently, signalling molecules and pathways which are responsible for the initiation and progression of this disease have been under intense scrutiny. One important signalling molecule, nuclear factor κB (NF-κB), has been shown to play a critical role in the development of acute pancreatitis. NF-κB is a nuclear transcription factor responsible for regulating the transcription of a wide variety of genes involved in immunity and inflammation. Many of these genes have been implicated as central players in the development and progression of acute pancreatitis. This review discusses recent advances in the investigation of pancreatic and extrapancreatic (lungs, liver, monocytes and macrophages, and endothelial cells) NF-κB activation as it relates to acute pancreatitis.",
author = "Z. Rakonczay and P. Hegyi and T. Tak{\'a}cs and J. McCarroll and Saluja, {A. K.}",
year = "2008",
month = "2",
doi = "10.1136/gut.2007.124115",
language = "English",
volume = "57",
pages = "259--267",
journal = "Gut",
issn = "0017-5749",
publisher = "BMJ Publishing Group",
number = "2",

}

TY - JOUR

T1 - The role of NF-κB activation in the pathogenesis of acute pancreatitis

AU - Rakonczay, Z.

AU - Hegyi, P.

AU - Takács, T.

AU - McCarroll, J.

AU - Saluja, A. K.

PY - 2008/2

Y1 - 2008/2

N2 - Acute pancreatitis is an inflammatory disease of the pancreas which, in its most severe form, is associated with multi-organ failure and death. Recently, signalling molecules and pathways which are responsible for the initiation and progression of this disease have been under intense scrutiny. One important signalling molecule, nuclear factor κB (NF-κB), has been shown to play a critical role in the development of acute pancreatitis. NF-κB is a nuclear transcription factor responsible for regulating the transcription of a wide variety of genes involved in immunity and inflammation. Many of these genes have been implicated as central players in the development and progression of acute pancreatitis. This review discusses recent advances in the investigation of pancreatic and extrapancreatic (lungs, liver, monocytes and macrophages, and endothelial cells) NF-κB activation as it relates to acute pancreatitis.

AB - Acute pancreatitis is an inflammatory disease of the pancreas which, in its most severe form, is associated with multi-organ failure and death. Recently, signalling molecules and pathways which are responsible for the initiation and progression of this disease have been under intense scrutiny. One important signalling molecule, nuclear factor κB (NF-κB), has been shown to play a critical role in the development of acute pancreatitis. NF-κB is a nuclear transcription factor responsible for regulating the transcription of a wide variety of genes involved in immunity and inflammation. Many of these genes have been implicated as central players in the development and progression of acute pancreatitis. This review discusses recent advances in the investigation of pancreatic and extrapancreatic (lungs, liver, monocytes and macrophages, and endothelial cells) NF-κB activation as it relates to acute pancreatitis.

UR - http://www.scopus.com/inward/record.url?scp=38549084647&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38549084647&partnerID=8YFLogxK

U2 - 10.1136/gut.2007.124115

DO - 10.1136/gut.2007.124115

M3 - Article

C2 - 17675325

AN - SCOPUS:38549084647

VL - 57

SP - 259

EP - 267

JO - Gut

JF - Gut

SN - 0017-5749

IS - 2

ER -