A neoadjuváns kezelés szerepe a nyaki szakaszon elhelyezkedo elorehaladott nyelocsolaphámrákok sebészi kezelésében.

Translated title of the contribution: [The role of neoadjuvant therapy in the treatment of locally advanced squamous cell cancer of the cervical oesophagus].

András Papp, László Cseke, Gábor Varga, Gábor Pavlovics, László Potó, Sándor Márton, Róbert Farkas, Szabolcs Bellyei, Ors Péter Horváth

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Cervical oesophagus represents a critical location for squamous cell carcinoma, which usually requires extensive surgery (pharyngo-laryngo-oesophagectomy). In the last decade, neoadjuvant chemo-radiotherapy was reported to be beneficial in the treatment of locally advanced squamous cell oesophageal cancer. Between November 1997 and January 2012, 55 patients with locally advanced (T3-4) squamous cell oesophageal cancer received preoperative chemo-radiotherapy, where the tumour was localized in the upper third. Patients received preoperative irradiation of 3960 cGy in 180 cGy fractions and simultaneously Cisplatin and 5-FU chemotherapy. Restaging was carried out after four weeks and patients considered operable were underwent surgery. In patients with cervical oesophageal cancer 35 of 55 (64%) underwent oesophageal resection or pharyngo-laryngectomy. In 16 out of 35 resected specimens (46%) complete histopathological remission (pCR) was observed. Perioperative mortality and anastomotic leaks were the same: 5/35 (14%). R0 resection rate was 82% and the 2- and 5 years survival rates were 41% and 18%. In 19 cases a larynx preserving pharyngo-oesophagectomy was performed and a free jejunal graft was used for reconstruction after a pharyngo-laryngectomy in 11 cases. The high rate of pCR (46%) confirmed that upper third oesophageal cancer has superior sensitivity to multimodal treatment. In 30 cases neoadjuvant chemo-radiotherapy was able to achieve tumour regression and render pharyngo-laryngo-oesophagectomy unnecessary.

Translated title of the contribution[The role of neoadjuvant therapy in the treatment of locally advanced squamous cell cancer of the cervical oesophagus].
Original languageHungarian
Pages (from-to)340-347
Number of pages8
JournalMagyar sebészet
Volume65
Issue number5
DOIs
Publication statusPublished - Oct 2012

ASJC Scopus subject areas

  • Medicine(all)

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