A myocardialis apoptosis szerepe a szívelégtelenség kialakulásában.

Translated title of the contribution: The role of myocardial apoptosis in the development of heart failure

P. Andréka, G. Müzes, Z. Nádházi

Research output: Contribution to journalReview article

Abstract

Heart failure can result from a variety of causes, including volume or pressure overload and contractile disturbances of the myocardium. Loss of myocytes is an important mechanism in the development of cardiac failure. In general, myocyte death resulting in progressive deterioration of myocardial function is attributed to necrosis, but recently the involvement of programmed cell death (mainly apoptosis) has been suggested. The authors review the possible role of myocardial apoptosis in developing of heart failure. Subcellular genetic regulatory processes as well as the pharmacological susceptibility of programmed cell death are also discussed. In heart failure, significant amount of cardiac myocytes undergoes apoptosis, that unlike necrosis can be prevented. Specific inhibition of this process could mean a considerable part of cardioprotection after thorough understanding of the underlying cellular mechanisms.

Original languageHungarian
Pages (from-to)135-142
Number of pages8
JournalOrvosi hetilap
Volume140
Issue number3
Publication statusPublished - Jan 17 1999

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ASJC Scopus subject areas

  • Medicine(all)

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