The role of mitochondrial Ca2+ and NAD(P)H in the control of aldosterone secretion

Research output: Contribution to journalArticle

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Abstract

The mineralocorticoid hormone aldosterone is synthesized in the zona glomerulosa of the adrenal cortex. Glomerulosa cells respond to the physiological stimuli, elevated extracellular [K+] and angiotensin II, with an intracellular Ca2+ signal. Cytosolic Ca2+ facilitates the transport of the steroid-precursor cholesterol to mitochondria and, after a few hours, it also induces the transcription of aldosterone synthase. Therefore, the cytosolic Ca2+ signal is regarded as the most important short and long-term mediator of aldosterone secretion. However, cytosolic Ca2+ is also taken up by mitochondria and, in turn, the mitochondrial Ca2+ response activates mitochondrial dehydrogenases resulting in stimulation of respiration and increase in reduced pyridine nucleotides. Since both cholesterol side-chain cleavage and all of the hydroxylation steps of steroid synthesis require NADPH as a cofactor, the importance of cytosolic Ca2+ - mitochondrial Ca2+ coupling and of appropriate NADPH supply in respect to hormone production can be assumed. However, the importance of the mitochondrial factors has been neglected so far. Here, after summarizing earlier findings we provide new results obtained through modifying mitochondrial Ca2+ uptake by knocking down p38 MAPK or OPA1 and overexpressing S100G, supporting the notion that mitochondrial Ca2+ and reduced pyridine nucleotides are facilitating factors for both basal and stimulated steroid production.

Original languageEnglish
Pages (from-to)64-72
Number of pages9
JournalCell Calcium
Volume52
Issue number1
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Aldosterone
NAD
Steroids
NADP
Mitochondria
Nucleotides
Cholesterol
Cytochrome P-450 CYP11B2
Hormones
Zona Glomerulosa
Mineralocorticoids
Adrenal Cortex
p38 Mitogen-Activated Protein Kinases
Hydroxylation
Angiotensin II
Oxidoreductases
Respiration
pyridine

Keywords

  • Aldosterone
  • Angiotensin II
  • Calcium
  • Mitochondria
  • OPA1
  • p38 MAPK
  • Potassium
  • Pyridine nucleotides
  • S100G

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

Cite this

The role of mitochondrial Ca2+ and NAD(P)H in the control of aldosterone secretion. / Spät, A.; Fülöp, L.; Szanda, G.

In: Cell Calcium, Vol. 52, No. 1, 07.2012, p. 64-72.

Research output: Contribution to journalArticle

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