The role of mitochondria in the activation/maintenance of SOCE store-operated Ca2+ entry and mitochondria

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Mitochondria modify cellular Ca2+ transport processes and, in turn, almost every Ca2+ signaling event has a notable effect on mitochondrial function. This kind of reciprocal interplay between Ca2+ handling and mitochondria is especially prominent during store-operated Ca2+ entry (SOCE). Localization of mitochondria, Ca2+ uptake and efflux into and out of the organelle, and even release of metabolites from the mitochondria have been shown to substantially modify SOCE. On the other hand, Ca2+ entering the cell through store-operated channels is sequestered by mitochondria. The ensuing mitochondrial Ca2+ signal activates the reduction of pyridine nucleotides and promotes ATP synthesis and thereby adjusts energy metabolism to cellular demands. Mitochondrial Ca2+ accumulation also supports cell specific functions such as steroid and insulin secretion. Early observations have suggested that mitochondria need to be localized in the vicinity of store-operated channels for efficient SOCE to occur. Recent studies in numerous cell types, however, have shown that mitochondria are not located in the molecular proximity of store-operated channels but Ca2+diffuses to mitochondria from the nearby orifice of the channels. Consequently, the formation of high Ca2+ perimitochondrial microdomains is not a sine qua non for SOCE-mitochondrion cooperation.

Original languageEnglish
Title of host publicationStore-operated Ca2+ entry (SOCE) pathways: Emerging signaling concepts in human (patho)physiology
PublisherSpringer-Verlag Wien
Pages177-192
Number of pages16
Volume9783709109625
ISBN (Print)9783709109625, 3709109612, 9783709109618
DOIs
Publication statusPublished - Nov 1 2012

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Mitochondria
Chemical activation
Maintenance
Metabolites
Orifices
Organelles
Energy Metabolism
Nucleotides
Adenosine Triphosphate
Steroids
Insulin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Spät, A., & Szanda, G. (2012). The role of mitochondria in the activation/maintenance of SOCE store-operated Ca2+ entry and mitochondria. In Store-operated Ca2+ entry (SOCE) pathways: Emerging signaling concepts in human (patho)physiology (Vol. 9783709109625, pp. 177-192). Springer-Verlag Wien. https://doi.org/10.1007/978-3-7091-0962-5_13

The role of mitochondria in the activation/maintenance of SOCE store-operated Ca2+ entry and mitochondria. / Spät, A.; Szanda, G.

Store-operated Ca2+ entry (SOCE) pathways: Emerging signaling concepts in human (patho)physiology. Vol. 9783709109625 Springer-Verlag Wien, 2012. p. 177-192.

Research output: Chapter in Book/Report/Conference proceedingChapter

Spät, A & Szanda, G 2012, The role of mitochondria in the activation/maintenance of SOCE store-operated Ca2+ entry and mitochondria. in Store-operated Ca2+ entry (SOCE) pathways: Emerging signaling concepts in human (patho)physiology. vol. 9783709109625, Springer-Verlag Wien, pp. 177-192. https://doi.org/10.1007/978-3-7091-0962-5_13
Spät A, Szanda G. The role of mitochondria in the activation/maintenance of SOCE store-operated Ca2+ entry and mitochondria. In Store-operated Ca2+ entry (SOCE) pathways: Emerging signaling concepts in human (patho)physiology. Vol. 9783709109625. Springer-Verlag Wien. 2012. p. 177-192 https://doi.org/10.1007/978-3-7091-0962-5_13
Spät, A. ; Szanda, G. / The role of mitochondria in the activation/maintenance of SOCE store-operated Ca2+ entry and mitochondria. Store-operated Ca2+ entry (SOCE) pathways: Emerging signaling concepts in human (patho)physiology. Vol. 9783709109625 Springer-Verlag Wien, 2012. pp. 177-192
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