The role of microRNAs in the pathogenesis of autoimmune diseases

Ji Qing Chen, Gábor Papp, Péter Szodoray, M. Zeher

Research output: Contribution to journalReview article

118 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are single-stranded, endogenous non-coding small RNAs, ranging from 18 to 25 nucleotides in length. Growing evidence suggests that miRNAs are essential in regulating gene expression, cell development, differentiation and function. Autoimmune diseases are a family of chronic systemic inflammatory diseases. Recent findings on miRNA expression profiles have been suggesting their role as biomarkers in autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis and Sjögren's syndrome. In this review, we summarize the characteristics of miRNAs and their functional role in the immune system and autoimmune diseases including systemic lupus erythematosus, primary Sjögren's syndrome, rheumatoid arthritis, systemic sclerosis, multiple sclerosis and psoriasis; moreover, we depict the advantages of miRNAs in modern diagnostics.

Original languageEnglish
Pages (from-to)1171-1180
Number of pages10
JournalAutoimmunity Reviews
Volume15
Issue number12
DOIs
Publication statusPublished - Dec 1 2016

Keywords

  • MicroRNAs (miRs)
  • Multiple sclerosis (MS)
  • Primary Sjögren's syndrome (SS)
  • Psoriasis
  • Rheumatoid arthritis (RA)
  • Systemic lupus erythematosus (SLE)
  • Systemic sclerosis (SSc)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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