The role of lymphoid cells and polymorphonuclear leukocytes in the pathogenesis of psoriasis

R. H. Cormane, J. Hunyadi, F. Hamerlinck

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The occurrence of antinuclear antibodies (ANA) in eluates of lymphoid cells and granulocytes obtained in 7 untreated psoriasis patients could be demonstrated by means of the indirect immunofluorescence technique. These antibodies appear to be non specific and are mainly directed against the nuclei of the basal cell layer of uninvolved skin, but ANA directed against the nuclei of epidermal and dermal cells were as well. Moreover, a significant decrease of circulating lymphoid cells forming rosettes with sheep erythrocytes have been found, suggesting a diminution of T cell control. The immunologic mechanisms in psoriasis may therefore be looked upon as being due to a lack of T cell suppressor genes facilitating the recognition of nuclear basal cell self antigens and a subsequent production of multiclonal anti basal cell nuclear antibodies. These antibodies may interfere with the function of membrane bound enzymes which serve as a regulatory epidermal control mechanisms. Various exogenous and endogenous factors may help to initiate the immune response leading to a cell mediated immune response at the onset of a lesion and an Arthus type reaction located in the upper layers of the epidermis at a later stage of the disease. Consequently the course of events in psoriasis is a self perpetuating inflammatory process.

Original languageEnglish
Pages (from-to)247-259
Number of pages13
JournalJournal of Dermatology
Volume3
Issue number5
Publication statusPublished - 1976

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Psoriasis
Neutrophils
Lymphocytes
Antinuclear Antibodies
Antibodies
Arthus Reaction
Suppressor Genes
T-Lymphocytes
Skin
Autoantigens
Indirect Fluorescent Antibody Technique
Basal Ganglia
Cell Nucleus
Granulocytes
Epidermis
Sheep
Erythrocytes
Membranes
Enzymes

ASJC Scopus subject areas

  • Dermatology

Cite this

The role of lymphoid cells and polymorphonuclear leukocytes in the pathogenesis of psoriasis. / Cormane, R. H.; Hunyadi, J.; Hamerlinck, F.

In: Journal of Dermatology, Vol. 3, No. 5, 1976, p. 247-259.

Research output: Contribution to journalArticle

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N2 - The occurrence of antinuclear antibodies (ANA) in eluates of lymphoid cells and granulocytes obtained in 7 untreated psoriasis patients could be demonstrated by means of the indirect immunofluorescence technique. These antibodies appear to be non specific and are mainly directed against the nuclei of the basal cell layer of uninvolved skin, but ANA directed against the nuclei of epidermal and dermal cells were as well. Moreover, a significant decrease of circulating lymphoid cells forming rosettes with sheep erythrocytes have been found, suggesting a diminution of T cell control. The immunologic mechanisms in psoriasis may therefore be looked upon as being due to a lack of T cell suppressor genes facilitating the recognition of nuclear basal cell self antigens and a subsequent production of multiclonal anti basal cell nuclear antibodies. These antibodies may interfere with the function of membrane bound enzymes which serve as a regulatory epidermal control mechanisms. Various exogenous and endogenous factors may help to initiate the immune response leading to a cell mediated immune response at the onset of a lesion and an Arthus type reaction located in the upper layers of the epidermis at a later stage of the disease. Consequently the course of events in psoriasis is a self perpetuating inflammatory process.

AB - The occurrence of antinuclear antibodies (ANA) in eluates of lymphoid cells and granulocytes obtained in 7 untreated psoriasis patients could be demonstrated by means of the indirect immunofluorescence technique. These antibodies appear to be non specific and are mainly directed against the nuclei of the basal cell layer of uninvolved skin, but ANA directed against the nuclei of epidermal and dermal cells were as well. Moreover, a significant decrease of circulating lymphoid cells forming rosettes with sheep erythrocytes have been found, suggesting a diminution of T cell control. The immunologic mechanisms in psoriasis may therefore be looked upon as being due to a lack of T cell suppressor genes facilitating the recognition of nuclear basal cell self antigens and a subsequent production of multiclonal anti basal cell nuclear antibodies. These antibodies may interfere with the function of membrane bound enzymes which serve as a regulatory epidermal control mechanisms. Various exogenous and endogenous factors may help to initiate the immune response leading to a cell mediated immune response at the onset of a lesion and an Arthus type reaction located in the upper layers of the epidermis at a later stage of the disease. Consequently the course of events in psoriasis is a self perpetuating inflammatory process.

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