The role of local anesthetic effect in the inhibition of glycogenolysis in the liver of the rat

G. Pogatsa, A. Kaldor, E. S. Vizi

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Abstract

The mechanisms of the inhibitory effect of β adrenergic antagonists and hypoglycemic sulphonylurea respectively on liver glycogenolysis has been investigated. It was demonstrated that, similarly to β adrenergic antagonists, the sulphonylureas also have a local anesthetic effect. Both the β antagonist LB 46, void of local anesthetic, were furthermore found to inhibit in the rat liver isoprenaline induced increase of glucose release and glycogenolysis. At the same time, enhanced liver glycogenolysis actuated by the absence of sugar from the perfusion fluid was not influenced either by LB 46 or by procaine.

Original languageEnglish
Pages (from-to)1085-1087
Number of pages3
JournalArzneimittel-Forschung/Drug Research
Volume23
Issue number8
Publication statusPublished - Dec 1 1973

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ASJC Scopus subject areas

  • Drug Discovery

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