The role of intraamygdaloid neurotensin and dopamine interaction in conditioned place preference

K. László, L. Péczely, A. Kovács, O. Zagoracz, T. Ollmann, E. Kertes, V. Kállai, B. Csetényi, Z. Karádi, L. Lénárd

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Tridecapeptide Neurotensin (NT) is widely distributed in the central nervous system where it acts as a neurotransmitter and neuromodulator. The central nucleus of amygdala (CeA), part of the limbic system, plays an important role in learning, memory, anxiety and reinforcing mechanisms. Our previous data showed that NT microinjected into the CeA has positive reinforcing properties. We supposed that these effects might be due to modulations of the mesolimbic dopamine system. The aim of our study was to examine in the CeA the possible effects of NT and dopamine interaction on reinforcement by conditioned place preference test. Male Wistar rats were microinjected bilaterally with 100 ng NT or 2 μg D1 dopamine receptor antagonist alone, or D1 dopamine antagonist 15 min before 100 ng NT treatment or vehicle solution into the CeA. Other animals received 4 μg D2 dopamine receptor antagonist Sulpiride alone, or administration of D2 dopamine receptor antagonist 15 min before 100 ng NT treatment or vehicle solution into the CeA. Rats that received 100 ng NT spent significantly more time in the treatment quadrant during the test session. Pre-treatment with the D1 dopamine antagonist, blocked the effects of NT. D2 dopamine receptor antagonist pretreatment could prevent the positive reinforcing effects of NT as well. Antagonists themselves did not influence the place preference. Our results show that the rewarding effect of NT can be due to the modulation of DA system, since its effects could be blocked by either D1 dopamine or D2 dopamine antagonist preteatment.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalBehavioural Brain Research
Volume344
DOIs
Publication statusPublished - May 15 2018

Fingerprint

Neurotensin
Dopamine
Dopamine Antagonists
Neurotransmitter Agents
Limbic System
Sulpiride
Wistar Rats
Anxiety
Central Nervous System
Central Amygdaloid Nucleus
Learning

Keywords

  • Amygdala
  • D1 dopamine receptor
  • D2 dopamine receptor
  • Neurotensin
  • Place preference
  • Positive reinforcement
  • Rat

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

The role of intraamygdaloid neurotensin and dopamine interaction in conditioned place preference. / László, K.; Péczely, L.; Kovács, A.; Zagoracz, O.; Ollmann, T.; Kertes, E.; Kállai, V.; Csetényi, B.; Karádi, Z.; Lénárd, L.

In: Behavioural Brain Research, Vol. 344, 15.05.2018, p. 85-90.

Research output: Contribution to journalArticle

László, K, Péczely, L, Kovács, A, Zagoracz, O, Ollmann, T, Kertes, E, Kállai, V, Csetényi, B, Karádi, Z & Lénárd, L 2018, 'The role of intraamygdaloid neurotensin and dopamine interaction in conditioned place preference', Behavioural Brain Research, vol. 344, pp. 85-90. https://doi.org/10.1016/j.bbr.2018.01.021
László, K. ; Péczely, L. ; Kovács, A. ; Zagoracz, O. ; Ollmann, T. ; Kertes, E. ; Kállai, V. ; Csetényi, B. ; Karádi, Z. ; Lénárd, L. / The role of intraamygdaloid neurotensin and dopamine interaction in conditioned place preference. In: Behavioural Brain Research. 2018 ; Vol. 344. pp. 85-90.
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AU - Kertes, E.

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