Az intestinalis alkalikus foszfatáz szerepe gyermekkori gyulladásos bélbetegségben és coeliakiában

Translated title of the contribution: The role of intestinal alkaline phosphatase in pediatric infl ammatory bowel and celiac diseases

Kriszta Molnár, Ádám Vannay, Erna Sziksz, Nóra Fanni Bánki, Áron Cseh, Hajnalka Gyórffy, Antal Dezsófi, András Arató, Gábor Veres

Research output: Contribution to journalArticle

Abstract

Intestinal alkaline phosphatase enzyme plays a pivotal role in the maintenance of intestinal mucosal barrier integrity with the detoxification capacity of lipopolysaccharide, the ligand of Toll-like receptor 4. The inappropriate immune responses and the damage of the mucosal barrier may contribute to the initiation of inflammatory bowel and celiac diseases. In the inflamed colonic mucosa of children with inflammatory bowel disease and in the duodenal mucosa of newly diagnosed children with celiac disease, the decreased intestinal alkaline phosphatase and increased Toll-like receptor 4 protein expression may generate enhanced lipopolysaccharide activity, which may strengthen tissue damaging processes. The enhancement of intestinal alkaline phosphatase activity in an animal model of colitis and in therapy resistant, adult patients with ulcerative colitis reduced the symptoms of intestinal inflammation. In accordance with these results, the targeted intestinal administration of the enzyme in the two examined disorders may be a supplemental therapeutic option in the future.

Original languageHungarian
Pages (from-to)1389-1395
Number of pages7
JournalOrvosi hetilap
Volume153
Issue number35
DOIs
Publication statusPublished - Sep 1 2012

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ASJC Scopus subject areas

  • Medicine(all)

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