Az interleukin-1 béta szerepe a májspecifikus génexpressziók szabályozásában humán hepatoblastoma sejtekben.

Translated title of the contribution: The role of interleukin-1 beta in the regulation of liver-specific gene expression in human hepatoblastoma cells

G. Lengyel, B. Joachim, G. Acs, J. Fehér

Research output: Contribution to journalArticle

Abstract

The authors studied the function of liver cells--on level of DNA and gene regulation--by methods of molecular biology. They found that treating human hepatoma (Hep G2) cells with interleukin-1 (IL-1) leads to the induction of alpha-1-acidglycoprotein (AGP) and complement 3 (C3) mRNA synthesis, and to a concomitant downregulation of albumin (alb), alpha-fetoprotein (AFP) and alpha-2-macroglobulin (alpha 2M) mRNA synthesis. Levels of specific mRNA were measured by Northern-blot analysis. They conclude that Hep G2 cells may serve as a suitable in vitro model for study of the liver specific gene expression, and IL-1 is one of the mediators of these gene control. The regulation is pretranslational as the direction of change in specific mRNA corresponds to the changes in synthesis of the respective proteins.

Original languageHungarian
Pages (from-to)2299-2300, 2303
JournalOrvosi Hetilap
Volume131
Issue number42
Publication statusPublished - Oct 21 1990

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Hepatoblastoma
Interleukin-1beta
Gene Expression
Messenger RNA
Liver
Hep G2 Cells
Interleukin-1
alpha-Macroglobulins
Complement C3
alpha-Fetoproteins
Northern Blotting
Genes
Molecular Biology
Albumins
Hepatocellular Carcinoma
Down-Regulation
DNA
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Az interleukin-1 béta szerepe a májspecifikus génexpressziók szabályozásában humán hepatoblastoma sejtekben. / Lengyel, G.; Joachim, B.; Acs, G.; Fehér, J.

In: Orvosi Hetilap, Vol. 131, No. 42, 21.10.1990, p. 2299-2300, 2303.

Research output: Contribution to journalArticle

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