Az inzulinszerü növekedési faktort kötö fehérje-3 helye az acromegalia aktivitásának megítélésében.

Translated title of the contribution: The role of insulin-like-growth-factor-binding protein 3 in the evaluation of disease activity in acromegaly

E. Hubina, M. Góth, L. Kovács, I. Szabolcs, E. Rimanóczy, A. Ferencz, S. Czirják, G. Szilágyi

Research output: Contribution to journalArticle

Abstract

Studied the diagnostic value of measurements of insulin-like growth factor binding protein-3 compared to insulin-like growth factor-1 as a parameter of disease activity in patients with active (n = 12, 8 females, 4 males, 29-69 years old) and inactive (n = 14, 11 females, 3 males, 28-58 years old) acromegaly. Patients were assigned to the active group if they had GH levels > or = 2 ng/ml, to the inactive group if they had growth hormone levels <2 ng/ml after 75 g glucose challenge. The absolute serum insulin-like growth factor-1 concentration (526 +/- 66 ng/ml vs. 272 +/- 61 ng/ml, p = 0.015; mean +/- SE) and the insulin-like growth factor-1 standard deviation score (3.23 +/- 0.33 vs. 0.67 +/- 0.58, p = 0.0013) was higher in the active than in the inactive group, but no significant difference was seen between the corresponding insulin-like growth factor binding protein-3 values (7270 +/- 1500 vs. 5340 +/- 1050 ng/ml). Positive significant correlation was found between insulin-like growth factor-1 and insulin-like growth factor binding protein-3 both in the active (n = 12, r = 0.55, p <0.05) and in the inactive (n = 14, r = 0.61, p <0.05) group. A significant negative correlation existed between insulin-like growth factor binding protein-3 and age in the inactive (r = 0.58, n = 14; p <0.05), but not in the active (r = 0.35, n = 12) group. The diagnostic value of insulin-like growth factor binding protein-3 is less than that of the insulin-like growth factor-1. Conclude that the insulin-like growth factor binding protein-3 has smaller suitability to determine the activity of acromegaly than the insulin like-growth factor-1 measurement.

Original languageHungarian
Pages (from-to)2345-2347
Number of pages3
JournalOrvosi Hetilap
Volume140
Issue number42
Publication statusPublished - Oct 17 1999

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Insulin-Like Growth Factor Binding Protein 3
Acromegaly
Somatomedins
Growth Hormone
Glucose
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Az inzulinszerü növekedési faktort kötö fehérje-3 helye az acromegalia aktivitásának megítélésében. / Hubina, E.; Góth, M.; Kovács, L.; Szabolcs, I.; Rimanóczy, E.; Ferencz, A.; Czirják, S.; Szilágyi, G.

In: Orvosi Hetilap, Vol. 140, No. 42, 17.10.1999, p. 2345-2347.

Research output: Contribution to journalArticle

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AU - Góth, M.

AU - Kovács, L.

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