Az inzulin szerepe a tápláléfölvétel központi idegrendszeri szabályozásában. Irodalmi öszefoglaló

Translated title of the contribution: The role of insulin in the central regulation of feed-intake. Literature review

Kiss Dálvid Sándor, Jócsák Gergely, Zsarnovszky Attila

Research output: Contribution to journalReview article

Abstract

The authors review the role of insulin, individually and in combinations with ghrelin, leptin, oestrogen and thyroid hormones, in the central regulation of feed-intake. The afore-listed hormones target the neuropeptide Y- (NPY) and pro-opiomelanocortin- (POMC) containing neurons of the hypothalamus, where they regulate feed-intake through the activation of cognate hormone receptors. Hypothalamic NPY and POMC neurons interact with relevant brain centres also involved in the regulation of feed-intake and with peripheral tissues on a feedback basis. The complex and integrated regulatory machinery of feed-intake involves the activation of relevant neural circuits through hormone receptor-activation in conjunction with the activation of intracellular signalling cascades, as a result of which the connectivity pattern of the softwired hypothalamus is set to regulate the actual metabolic needs of the organism.

Translated title of the contributionThe role of insulin in the central regulation of feed-intake. Literature review
Original languageHungarian
Pages (from-to)635-640
Number of pages6
JournalMagyar Allatorvosok Lapja
Volume134
Issue number10
Publication statusPublished - Oct 1 2012

ASJC Scopus subject areas

  • veterinary(all)

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