The authors review the role of insulin, individually and in combinations with ghrelin, leptin, oestrogen and thyroid hormones, in the central regulation of feed-intake. The afore-listed hormones target the neuropeptide Y- (NPY) and pro-opiomelanocortin- (POMC) containing neurons of the hypothalamus, where they regulate feed-intake through the activation of cognate hormone receptors. Hypothalamic NPY and POMC neurons interact with relevant brain centres also involved in the regulation of feed-intake and with peripheral tissues on a feedback basis. The complex and integrated regulatory machinery of feed-intake involves the activation of relevant neural circuits through hormone receptor-activation in conjunction with the activation of intracellular signalling cascades, as a result of which the connectivity pattern of the softwired hypothalamus is set to regulate the actual metabolic needs of the organism.
|Translated title of the contribution||The role of insulin in the central regulation of feed-intake. Literature review|
|Number of pages||6|
|Journal||Magyar Allatorvosok Lapja|
|Publication status||Published - Oct 1 2012|
ASJC Scopus subject areas