The role of insertion allele of angiotensin converting enzyme gene in higher endurance efficiency and some aspects of pathophysiological and drug effects

M. Dékány, I. Harbula, I. Berkes, I. Györe, A. Falus, J. Pucsok

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: None of the genetic markers are selectively associated with elite athletes, but potential candidates are found in the renin-angiotensin system, which plays a key role in the regulation of cardiovascular physiology. The most extensively examined gene in connection with the hemodynamics category is the angiotensin converting enzyme (ACE). This review paper has focused on ACE I/D allele polymorphism regarding the evidence of the effects of physiological and pathophysiological drugs and has completed with an original work in the exercise physiology. Methods: In this study we examined genetic polymorphisms of ACE in female (n=26) and male (n=24) athletes as well as in a well-trained control group (n=24).MVVex, VE and VO2max. were determined at rest and during an exhaustive step test. Results: The frequency of the ACE I allele was significantly higher (p

Original languageEnglish
Pages (from-to)2119-2126
Number of pages8
JournalCurrent Medicinal Chemistry
Volume13
Issue number18
DOIs
Publication statusPublished - Jul 2006

Fingerprint

Peptidyl-Dipeptidase A
Durability
Genes
Alleles
Physiology
Polymorphism
Athletes
Pharmaceutical Preparations
Physiological Effects of Drugs
Cardiovascular Physiological Phenomena
Angiotensins
Hemodynamics
Genetic Polymorphisms
Renin-Angiotensin System
Exercise Test
Genetic Markers
Renin
Exercise
Control Groups

Keywords

  • Angiotensin converting enzyme
  • Athletic excellence
  • Candidate genes
  • Physical endurance

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Pharmacology

Cite this

The role of insertion allele of angiotensin converting enzyme gene in higher endurance efficiency and some aspects of pathophysiological and drug effects. / Dékány, M.; Harbula, I.; Berkes, I.; Györe, I.; Falus, A.; Pucsok, J.

In: Current Medicinal Chemistry, Vol. 13, No. 18, 07.2006, p. 2119-2126.

Research output: Contribution to journalArticle

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