The role of innate immunity in the pathogenesis of acne

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115 Citations (Scopus)


Acne is a multifactorial disease of the pilosebaceous follicle. The most significant pathogenetic factors of acne are: abnormal ductal keratinization, increased sebum secretion, abnormalities of the microbial flora and inflammation. The pilosebaceous unit is an immunocompetent organ. Keratinocytes and sebocytes may act as immune cells capable of pathogen recognition and abnormal lipid presentation, and they might have an important role in initiating and perpetuating the activation of both innate and adaptive immune responses. The elements of the skin immune system are involved in the development of both noninflammatory and inflammatory acne lesions.

Original languageEnglish
Pages (from-to)96-105
Number of pages10
Issue number2
Publication statusPublished - Feb 24 2003


  • Acne
  • CD1d molecule
  • Toll-like receptors

ASJC Scopus subject areas

  • Dermatology

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