Az immunrendszer szerepe az endometriózis kifejlodésé ben

Translated title of the contribution: The role of immune system in the development of endometriosis

Fülöp Vilmos, Szigetvári Iván, Drávucz Sándor, Dancsó János

Research output: Contribution to journalReview article

Abstract

This article presents an overview of immunological factors and their role in the development of endometriosis, a quite frequent disease of women in reproductive age, with emphasis on inflammatory cytokines, growth and adhesion factors. Although retrograde menstruation is a common phenomenon among women of reproductive age, not all women who have retrograde menstruation develop endometriosis. The development of endometriosis is hypothesised to be a complex process, which may be facilitated by several factors, including the quantity and quality of endometrial cells in peritoneal fluid (PF), increased inflammatory activity in PF, increased endometrial-peritoneal adhesion and angiogenesis, reduced immune surveillance and clearance of endometrial cells, and increased production of autoantibodies against endometrial cells. Potential biomarkers like cytokines and autoantibodies upregulated during development of endometriosis may be useful in the development of a non-surgical diagnostic tool. Although endometriosis can be treated using hormonal suppression, there is need for non-hormonal drugs, which can inhibit the development of endometriosis and alleviate pain or infertility without inhibition of ovulation. New molecules that modulate immune function in endometriosis should be the targets for future research.

Translated title of the contributionThe role of immune system in the development of endometriosis
Original languageHungarian
Pages (from-to)225-233
Number of pages9
JournalMagyar Noorvosok Lapja
Volume68
Issue number4
Publication statusPublished - Jul 28 2005

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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  • Cite this

    Vilmos, F., Iván, S., Sándor, D., & János, D. (2005). Az immunrendszer szerepe az endometriózis kifejlodésé ben. Magyar Noorvosok Lapja, 68(4), 225-233.