Abstract
Hyperglycaemia has an important pathogenic role in the development of chronic diabetic complications. Elevated blood glucose level damages tissues by causing both acute, reversible changes in cellular metabolism and cumulative, irreversible alterations in stable macromolecules. Among the reversible abnormalities are the increased polyol pathway activity, the modified activation of protein kinase C, the enhanced oxidative stress and the formation of early glycosylation products. The most important irreversible change caused by hyperglycaemia is the formation and the accumulation of advanced glycosylation end-products (AGEs). The AGEs destroy the structure of basement membrane and the extracellular matrix, impair the endothelial and the vascular smooth muscle cell function and promote the thrombogenic changes. It is suggested that mitogen-activated protein kinases may be involved in the biochemical anomalies arising form hyperglycaemia.
| Original language | Hungarian |
|---|---|
| Pages (from-to) | 40-48 |
| Number of pages | 9 |
| Journal | Lege Artis Medicinae |
| Volume | 10 |
| Issue number | 1 |
| Publication status | Published - 2000 |
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ASJC Scopus subject areas
- Medicine(all)
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A hyperglykaemia szerepe a diabetes mellitus kesoi szovodmenyeinek kialakulasaban. / Hosszúfalusi, N.
In: Lege Artis Medicinae, Vol. 10, No. 1, 2000, p. 40-48.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A hyperglykaemia szerepe a diabetes mellitus kesoi szovodmenyeinek kialakulasaban
AU - Hosszúfalusi, N.
PY - 2000
Y1 - 2000
N2 - Hyperglycaemia has an important pathogenic role in the development of chronic diabetic complications. Elevated blood glucose level damages tissues by causing both acute, reversible changes in cellular metabolism and cumulative, irreversible alterations in stable macromolecules. Among the reversible abnormalities are the increased polyol pathway activity, the modified activation of protein kinase C, the enhanced oxidative stress and the formation of early glycosylation products. The most important irreversible change caused by hyperglycaemia is the formation and the accumulation of advanced glycosylation end-products (AGEs). The AGEs destroy the structure of basement membrane and the extracellular matrix, impair the endothelial and the vascular smooth muscle cell function and promote the thrombogenic changes. It is suggested that mitogen-activated protein kinases may be involved in the biochemical anomalies arising form hyperglycaemia.
AB - Hyperglycaemia has an important pathogenic role in the development of chronic diabetic complications. Elevated blood glucose level damages tissues by causing both acute, reversible changes in cellular metabolism and cumulative, irreversible alterations in stable macromolecules. Among the reversible abnormalities are the increased polyol pathway activity, the modified activation of protein kinase C, the enhanced oxidative stress and the formation of early glycosylation products. The most important irreversible change caused by hyperglycaemia is the formation and the accumulation of advanced glycosylation end-products (AGEs). The AGEs destroy the structure of basement membrane and the extracellular matrix, impair the endothelial and the vascular smooth muscle cell function and promote the thrombogenic changes. It is suggested that mitogen-activated protein kinases may be involved in the biochemical anomalies arising form hyperglycaemia.
KW - Advanced glycosylation ends-products
KW - Diabetes mellitus
KW - Diabetic complications
KW - Glycosylation
KW - Hyperglycaemia
KW - MAP kinase
UR - http://www.scopus.com/inward/record.url?scp=0033965470&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033965470&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0033965470
VL - 10
SP - 40
EP - 48
JO - Lege Artis Medicinae
JF - Lege Artis Medicinae
SN - 0866-4811
IS - 1
ER -