Hyperhomocysteinaemia szerepe az egyes érrendszeri betegségek kóreredetében.

Translated title of the contribution: The role of hyper-homocysteinemia in the etiology of some vascular diseases

E. Czeizel, L. Matos

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

About 5% of population have a highly, while other 15% a moderately elevated plasma homocysteine level. Hyperhomocysteinemia may be responsible about 10-20% of coronary artery, 40% of cerebrovascular and 60% of peripheral vascular diseases. There in an inverse relationship between folate, cobalamin and pyridoxine intake or blood level and plasma homocysteine level. In addition, the intake of these three B vitamins can reduce high plasma homocysteine level. Folate-folic acid seems to be the most important in homocysteine reduction due to the compensation of thermolabile methylenetetrahydrofolate reductase insufficiency, however, a milder impact of cobalamin any pyridoxine (mainly following a methionine load test) is also proved. There are possibilities to reduce risk associated with elevated homocysteine: e. g. dietary supplementation or food fortification. In Hungary bread enriched by folic acid, cobalamin and pyriodixine might reduce rate of vascular diseases due to hyperhomocysteinemia.

Original languageHungarian
Pages (from-to)2191-2196
Number of pages6
JournalOrvosi hetilap
Volume139
Issue number37
Publication statusPublished - Sep 13 1998

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ASJC Scopus subject areas

  • Medicine(all)

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