Hyperhomocysteinaemia szerepe az egyes érrendszeri betegségek kóreredetében.

Translated title of the contribution: The role of hyper-homocysteinemia in the etiology of some vascular diseases

E. Czeizel, L. Matos

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

About 5% of population have a highly, while other 15% a moderately elevated plasma homocysteine level. Hyperhomocysteinemia may be responsible about 10-20% of coronary artery, 40% of cerebrovascular and 60% of peripheral vascular diseases. There in an inverse relationship between folate, cobalamin and pyridoxine intake or blood level and plasma homocysteine level. In addition, the intake of these three B vitamins can reduce high plasma homocysteine level. Folate-folic acid seems to be the most important in homocysteine reduction due to the compensation of thermolabile methylenetetrahydrofolate reductase insufficiency, however, a milder impact of cobalamin any pyridoxine (mainly following a methionine load test) is also proved. There are possibilities to reduce risk associated with elevated homocysteine: e. g. dietary supplementation or food fortification. In Hungary bread enriched by folic acid, cobalamin and pyriodixine might reduce rate of vascular diseases due to hyperhomocysteinemia.

Translated title of the contributionThe role of hyper-homocysteinemia in the etiology of some vascular diseases
Original languageHungarian
Pages (from-to)2191-2196
Number of pages6
JournalOrvosi hetilap
Volume139
Issue number37
Publication statusPublished - Sep 13 1998

ASJC Scopus subject areas

  • Medicine(all)

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