The role of hyaluronic acid binding assay in choosing the fertilization method for patients undergoing IVF for unexplained infertility

Peter Kovacs, Timea Kovats, Attila Sajgo, J. Szöllősi, Szabolcs Matyas, Steven G. Kaali

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose: Patients with unexplained infertility may have fertilization problems. Split fertilization (ICSI and conventional IVF on sibling oocytes) is often used to avoid poor fertilization. Our aim was to assess the ability of hyaluronic acid binding (HA-binding) assay to predict spontaneous fertilization during IVF. Methods: Prospective, blinded, controlled trial. Patients undergoing their first IVF cycle for unexplained infertility were eligible. Split fertilization was used. IVF and ICSI fertilization rates and embryo development based on 3 HA-binding cut-offs (<60%; 60-80%; >80%) were compared. Results: ICSI fertilization was higher than IVF, but none of the HA-binding cut-off levels predicted those cases where IVF was less effective, therefore ICSI only would have lead to improved outcome. Embryo development and morphology were similar in all cut-off groups. Conclusions: HA-binding did not predict spontaneous fertilization in patients with unexplained infertility undergoing IVF treatment. When it was used for "screening" it did not help to select the method of fertilization.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalJournal of Assisted Reproduction and Genetics
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 2011

Fingerprint

Hyaluronic Acid
Fertilization
Infertility
Intracytoplasmic Sperm Injections
Embryonic Development
Aptitude
Oocytes
Siblings

Keywords

  • Fertilization rate
  • Hyaluronic acid binding
  • ICSI
  • Sibling oocytes
  • Unexplained infertility

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Developmental Biology
  • Genetics
  • Genetics(clinical)

Cite this

The role of hyaluronic acid binding assay in choosing the fertilization method for patients undergoing IVF for unexplained infertility. / Kovacs, Peter; Kovats, Timea; Sajgo, Attila; Szöllősi, J.; Matyas, Szabolcs; Kaali, Steven G.

In: Journal of Assisted Reproduction and Genetics, Vol. 28, No. 1, 01.2011, p. 49-54.

Research output: Contribution to journalArticle

@article{7f96c28492f9494eb7d0c2f82be92c23,
title = "The role of hyaluronic acid binding assay in choosing the fertilization method for patients undergoing IVF for unexplained infertility",
abstract = "Purpose: Patients with unexplained infertility may have fertilization problems. Split fertilization (ICSI and conventional IVF on sibling oocytes) is often used to avoid poor fertilization. Our aim was to assess the ability of hyaluronic acid binding (HA-binding) assay to predict spontaneous fertilization during IVF. Methods: Prospective, blinded, controlled trial. Patients undergoing their first IVF cycle for unexplained infertility were eligible. Split fertilization was used. IVF and ICSI fertilization rates and embryo development based on 3 HA-binding cut-offs (<60{\%}; 60-80{\%}; >80{\%}) were compared. Results: ICSI fertilization was higher than IVF, but none of the HA-binding cut-off levels predicted those cases where IVF was less effective, therefore ICSI only would have lead to improved outcome. Embryo development and morphology were similar in all cut-off groups. Conclusions: HA-binding did not predict spontaneous fertilization in patients with unexplained infertility undergoing IVF treatment. When it was used for {"}screening{"} it did not help to select the method of fertilization.",
keywords = "Fertilization rate, Hyaluronic acid binding, ICSI, Sibling oocytes, Unexplained infertility",
author = "Peter Kovacs and Timea Kovats and Attila Sajgo and J. Sz{\"o}llősi and Szabolcs Matyas and Kaali, {Steven G.}",
year = "2011",
month = "1",
doi = "10.1007/s10815-010-9479-3",
language = "English",
volume = "28",
pages = "49--54",
journal = "Journal of Assisted Reproduction and Genetics",
issn = "1058-0468",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - The role of hyaluronic acid binding assay in choosing the fertilization method for patients undergoing IVF for unexplained infertility

AU - Kovacs, Peter

AU - Kovats, Timea

AU - Sajgo, Attila

AU - Szöllősi, J.

AU - Matyas, Szabolcs

AU - Kaali, Steven G.

PY - 2011/1

Y1 - 2011/1

N2 - Purpose: Patients with unexplained infertility may have fertilization problems. Split fertilization (ICSI and conventional IVF on sibling oocytes) is often used to avoid poor fertilization. Our aim was to assess the ability of hyaluronic acid binding (HA-binding) assay to predict spontaneous fertilization during IVF. Methods: Prospective, blinded, controlled trial. Patients undergoing their first IVF cycle for unexplained infertility were eligible. Split fertilization was used. IVF and ICSI fertilization rates and embryo development based on 3 HA-binding cut-offs (<60%; 60-80%; >80%) were compared. Results: ICSI fertilization was higher than IVF, but none of the HA-binding cut-off levels predicted those cases where IVF was less effective, therefore ICSI only would have lead to improved outcome. Embryo development and morphology were similar in all cut-off groups. Conclusions: HA-binding did not predict spontaneous fertilization in patients with unexplained infertility undergoing IVF treatment. When it was used for "screening" it did not help to select the method of fertilization.

AB - Purpose: Patients with unexplained infertility may have fertilization problems. Split fertilization (ICSI and conventional IVF on sibling oocytes) is often used to avoid poor fertilization. Our aim was to assess the ability of hyaluronic acid binding (HA-binding) assay to predict spontaneous fertilization during IVF. Methods: Prospective, blinded, controlled trial. Patients undergoing their first IVF cycle for unexplained infertility were eligible. Split fertilization was used. IVF and ICSI fertilization rates and embryo development based on 3 HA-binding cut-offs (<60%; 60-80%; >80%) were compared. Results: ICSI fertilization was higher than IVF, but none of the HA-binding cut-off levels predicted those cases where IVF was less effective, therefore ICSI only would have lead to improved outcome. Embryo development and morphology were similar in all cut-off groups. Conclusions: HA-binding did not predict spontaneous fertilization in patients with unexplained infertility undergoing IVF treatment. When it was used for "screening" it did not help to select the method of fertilization.

KW - Fertilization rate

KW - Hyaluronic acid binding

KW - ICSI

KW - Sibling oocytes

KW - Unexplained infertility

UR - http://www.scopus.com/inward/record.url?scp=79952283288&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952283288&partnerID=8YFLogxK

U2 - 10.1007/s10815-010-9479-3

DO - 10.1007/s10815-010-9479-3

M3 - Article

C2 - 20842418

AN - SCOPUS:79952283288

VL - 28

SP - 49

EP - 54

JO - Journal of Assisted Reproduction and Genetics

JF - Journal of Assisted Reproduction and Genetics

SN - 1058-0468

IS - 1

ER -