The role of histamine in brain oedema formation.

F. Joó, J. Kovács, P. Szerdahelyi, P. Temesvári, A. Tósaki

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effects of histamine on the cerebral endothelial cells were studied. To determine if the extent of brain oedema formation could be reduced with histamine receptor antagonists, mepyramine (H1-receptor blocker), metiamide, cimetidine and ranitidine (H2-receptor antagonists) were administered at a dose of 5 mg/kg body weight 4, 2 and 0 h before the onset of experimental pneumothorax induced in newborn piglets. Mepyramine and ranitidine given 2 h before the induction of EBP prevented the accumulation of water, sodium and albumin in samples taken from the parietal cortex. In other experiments, carried out on Sprague-Dawley rats of CFY strain after permanent bilateral common carotid ligation (BCCL), the accumulation of water and sodium in the ischemic brain tissue could also be prevented in a dose dependent manner by intraperitoneal injections of ranitidine given 30 min before the surgery. Taken together, these results provide pharmacological evidence for the involvement of histamine receptors in the pathogenesis of brain oedema. Consequently, the use of histamine receptor blockers both in the prevention and in the treatment of brain oedema can be recommended.

Original languageEnglish
Pages (from-to)76-78
Number of pages3
JournalActa Neurochirurgica, Supplement
Volume60
Publication statusPublished - 1994

Fingerprint

Histamine Receptors
Ranitidine
Brain Edema
Histamine
Pyrilamine
Sodium
Metiamide
Histamine H1 Receptors
Parietal Lobe
Histamine H2 Receptors
Water
Histamine Antagonists
Cimetidine
Pneumothorax
Intraperitoneal Injections
Ligation
Sprague Dawley Rats
Albumins
Endothelial Cells
Body Weight

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology

Cite this

Joó, F., Kovács, J., Szerdahelyi, P., Temesvári, P., & Tósaki, A. (1994). The role of histamine in brain oedema formation. Acta Neurochirurgica, Supplement, 60, 76-78.

The role of histamine in brain oedema formation. / Joó, F.; Kovács, J.; Szerdahelyi, P.; Temesvári, P.; Tósaki, A.

In: Acta Neurochirurgica, Supplement, Vol. 60, 1994, p. 76-78.

Research output: Contribution to journalArticle

Joó, F, Kovács, J, Szerdahelyi, P, Temesvári, P & Tósaki, A 1994, 'The role of histamine in brain oedema formation.', Acta Neurochirurgica, Supplement, vol. 60, pp. 76-78.
Joó F, Kovács J, Szerdahelyi P, Temesvári P, Tósaki A. The role of histamine in brain oedema formation. Acta Neurochirurgica, Supplement. 1994;60:76-78.
Joó, F. ; Kovács, J. ; Szerdahelyi, P. ; Temesvári, P. ; Tósaki, A. / The role of histamine in brain oedema formation. In: Acta Neurochirurgica, Supplement. 1994 ; Vol. 60. pp. 76-78.
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