The role of hemorheological factors in cardiovascular medicine

A. Tóth, J. Papp, M. Rabai, P. Kenyeres, Zs Marton, G. Kesmarky, I. Juricskay, H. J. Meiselman, K. Tóth

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Cardiovascular diseases (CVD) are the most frequent cause of death throughout the world. The coronary vessel system is a special part of the circulation since there is a continuous change in blood flow, perfusion pressure and shear rate during each cardiac cycle. It is also the place of the narrowest capillaries in the human body, therefore the role of rheological alterations may be of greater importance than in the other parts of the circulatory system. During the past decades, our group has investigated hemorheological parameters (HP) in over 1,000 patients diagnosed with various forms of ischemic heart disease (IHD). In one prospective study, we measured the HP of patients with acute coronary syndrome (ACS). On admission, all examined variables were significantly worse than those of control subjects. During the hospital phase, some of the HP showed further deterioration, and HP remained in the pathologic range during the follow-up period. In another study, we showed that HP are in close correlation with the severity of coronary artery disease. In patients treated with percutaneous coronary intervention, changes in HP were very similar to those observed in subjects with ACS. In a recent study, we analyzed HP in patients undergoing CABG surgery. Our data suggest a hemorheological advantage of off-pump surgery. In another study low Hct/WBV ratio can be regarded as a risk factor of cardiac death in IHD. Our data indicate that rheological parameters are significantly altered in patients with IHD: the extent of the alterations is in excellent correlation with the clinical severity of the disease. Our findings prove that HP play a critical role in the pathogenesis of myocardial ischemia. In recent in vitro and in vivo studies we have investigated the effects of red wine on hemorheological parameters. Our results show that moderate red wine consumption has beneficial effects on hemorheological parameters which may contribute to the French paradox.

Original languageEnglish
Pages (from-to)197-204
Number of pages8
JournalClinical Hemorheology and Microcirculation
Volume56
Issue number3
DOIs
Publication statusPublished - 2014

Fingerprint

Medicine
Myocardial Ischemia
Wine
Acute Coronary Syndrome
Percutaneous Coronary Intervention
Cardiovascular System
Human Body
Coronary Artery Disease
Cause of Death
Coronary Vessels
Cardiovascular Diseases
Perfusion
Prospective Studies
Pressure

Keywords

  • acute coronary syndrome
  • coronary artery bypass grafting
  • ethanol
  • hematocrit per blood viscosity ratio
  • Ischemic heart disease
  • percutaneous coronary intervention
  • red wine

ASJC Scopus subject areas

  • Hematology
  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

The role of hemorheological factors in cardiovascular medicine. / Tóth, A.; Papp, J.; Rabai, M.; Kenyeres, P.; Marton, Zs; Kesmarky, G.; Juricskay, I.; Meiselman, H. J.; Tóth, K.

In: Clinical Hemorheology and Microcirculation, Vol. 56, No. 3, 2014, p. 197-204.

Research output: Contribution to journalArticle

Tóth, A. ; Papp, J. ; Rabai, M. ; Kenyeres, P. ; Marton, Zs ; Kesmarky, G. ; Juricskay, I. ; Meiselman, H. J. ; Tóth, K. / The role of hemorheological factors in cardiovascular medicine. In: Clinical Hemorheology and Microcirculation. 2014 ; Vol. 56, No. 3. pp. 197-204.
@article{0dff7905c4cf482a89fa1652a169719a,
title = "The role of hemorheological factors in cardiovascular medicine",
abstract = "Cardiovascular diseases (CVD) are the most frequent cause of death throughout the world. The coronary vessel system is a special part of the circulation since there is a continuous change in blood flow, perfusion pressure and shear rate during each cardiac cycle. It is also the place of the narrowest capillaries in the human body, therefore the role of rheological alterations may be of greater importance than in the other parts of the circulatory system. During the past decades, our group has investigated hemorheological parameters (HP) in over 1,000 patients diagnosed with various forms of ischemic heart disease (IHD). In one prospective study, we measured the HP of patients with acute coronary syndrome (ACS). On admission, all examined variables were significantly worse than those of control subjects. During the hospital phase, some of the HP showed further deterioration, and HP remained in the pathologic range during the follow-up period. In another study, we showed that HP are in close correlation with the severity of coronary artery disease. In patients treated with percutaneous coronary intervention, changes in HP were very similar to those observed in subjects with ACS. In a recent study, we analyzed HP in patients undergoing CABG surgery. Our data suggest a hemorheological advantage of off-pump surgery. In another study low Hct/WBV ratio can be regarded as a risk factor of cardiac death in IHD. Our data indicate that rheological parameters are significantly altered in patients with IHD: the extent of the alterations is in excellent correlation with the clinical severity of the disease. Our findings prove that HP play a critical role in the pathogenesis of myocardial ischemia. In recent in vitro and in vivo studies we have investigated the effects of red wine on hemorheological parameters. Our results show that moderate red wine consumption has beneficial effects on hemorheological parameters which may contribute to the French paradox.",
keywords = "acute coronary syndrome, coronary artery bypass grafting, ethanol, hematocrit per blood viscosity ratio, Ischemic heart disease, percutaneous coronary intervention, red wine",
author = "A. T{\'o}th and J. Papp and M. Rabai and P. Kenyeres and Zs Marton and G. Kesmarky and I. Juricskay and Meiselman, {H. J.} and K. T{\'o}th",
year = "2014",
doi = "10.3233/CH-131685",
language = "English",
volume = "56",
pages = "197--204",
journal = "Clinical Hemorheology and Microcirculation",
issn = "1386-0291",
publisher = "IOS Press",
number = "3",

}

TY - JOUR

T1 - The role of hemorheological factors in cardiovascular medicine

AU - Tóth, A.

AU - Papp, J.

AU - Rabai, M.

AU - Kenyeres, P.

AU - Marton, Zs

AU - Kesmarky, G.

AU - Juricskay, I.

AU - Meiselman, H. J.

AU - Tóth, K.

PY - 2014

Y1 - 2014

N2 - Cardiovascular diseases (CVD) are the most frequent cause of death throughout the world. The coronary vessel system is a special part of the circulation since there is a continuous change in blood flow, perfusion pressure and shear rate during each cardiac cycle. It is also the place of the narrowest capillaries in the human body, therefore the role of rheological alterations may be of greater importance than in the other parts of the circulatory system. During the past decades, our group has investigated hemorheological parameters (HP) in over 1,000 patients diagnosed with various forms of ischemic heart disease (IHD). In one prospective study, we measured the HP of patients with acute coronary syndrome (ACS). On admission, all examined variables were significantly worse than those of control subjects. During the hospital phase, some of the HP showed further deterioration, and HP remained in the pathologic range during the follow-up period. In another study, we showed that HP are in close correlation with the severity of coronary artery disease. In patients treated with percutaneous coronary intervention, changes in HP were very similar to those observed in subjects with ACS. In a recent study, we analyzed HP in patients undergoing CABG surgery. Our data suggest a hemorheological advantage of off-pump surgery. In another study low Hct/WBV ratio can be regarded as a risk factor of cardiac death in IHD. Our data indicate that rheological parameters are significantly altered in patients with IHD: the extent of the alterations is in excellent correlation with the clinical severity of the disease. Our findings prove that HP play a critical role in the pathogenesis of myocardial ischemia. In recent in vitro and in vivo studies we have investigated the effects of red wine on hemorheological parameters. Our results show that moderate red wine consumption has beneficial effects on hemorheological parameters which may contribute to the French paradox.

AB - Cardiovascular diseases (CVD) are the most frequent cause of death throughout the world. The coronary vessel system is a special part of the circulation since there is a continuous change in blood flow, perfusion pressure and shear rate during each cardiac cycle. It is also the place of the narrowest capillaries in the human body, therefore the role of rheological alterations may be of greater importance than in the other parts of the circulatory system. During the past decades, our group has investigated hemorheological parameters (HP) in over 1,000 patients diagnosed with various forms of ischemic heart disease (IHD). In one prospective study, we measured the HP of patients with acute coronary syndrome (ACS). On admission, all examined variables were significantly worse than those of control subjects. During the hospital phase, some of the HP showed further deterioration, and HP remained in the pathologic range during the follow-up period. In another study, we showed that HP are in close correlation with the severity of coronary artery disease. In patients treated with percutaneous coronary intervention, changes in HP were very similar to those observed in subjects with ACS. In a recent study, we analyzed HP in patients undergoing CABG surgery. Our data suggest a hemorheological advantage of off-pump surgery. In another study low Hct/WBV ratio can be regarded as a risk factor of cardiac death in IHD. Our data indicate that rheological parameters are significantly altered in patients with IHD: the extent of the alterations is in excellent correlation with the clinical severity of the disease. Our findings prove that HP play a critical role in the pathogenesis of myocardial ischemia. In recent in vitro and in vivo studies we have investigated the effects of red wine on hemorheological parameters. Our results show that moderate red wine consumption has beneficial effects on hemorheological parameters which may contribute to the French paradox.

KW - acute coronary syndrome

KW - coronary artery bypass grafting

KW - ethanol

KW - hematocrit per blood viscosity ratio

KW - Ischemic heart disease

KW - percutaneous coronary intervention

KW - red wine

UR - http://www.scopus.com/inward/record.url?scp=84901801220&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901801220&partnerID=8YFLogxK

U2 - 10.3233/CH-131685

DO - 10.3233/CH-131685

M3 - Article

VL - 56

SP - 197

EP - 204

JO - Clinical Hemorheology and Microcirculation

JF - Clinical Hemorheology and Microcirculation

SN - 1386-0291

IS - 3

ER -