Paraffin sections of 16 cases of partial mole, 25 cases of complet mole, 10 cases of gestational choriocarcinoma, and 11 cases of first-trimester placenta were studied immunohistochemically for gelatinases (MMP-2, MMP-9) and its inhibitor (TIMP-1) expression, furthermore the role of these enzymes were investigated in the induction of persistent gestational trophoblastic diseases. MMP-2 was expressed only in syncytio- and extravillous trophoblasts in normal placenta, partial mole and complet mole. Chorio-carcinoma and the extravillous trophoblast in partial mole and complet mole had significantly stronger staining for MMP-2 than the extravillous trophoblast in placenta (P=0,04, P<0,01, P<0,01, respectively). Choriocarcinoma also exhibited significantly stronger staining for MMP-2 than syncytiotrophoblasts in placenta (P<0,01), partial mole (P=0,05), and complet mole (P<0,01). The expression of MMP-9 was similar in all four tissues. While in most of the cases in placenta, partial and complet moles showed strong immunoreactivity for TIMP-1 in syncytiotrophoblasts, no strong staining was found in choriocarcinomas (P<0,01, P<0,01, P<0,01, respectively). Finally no correlation was found between the immunoreactivity of these enzymes and the development of persistent trophoblastic diseases. Supposingly gelatinases and their inhibitors may have an important role in the pathogenesis and progression of gestational trophoblastic diseases.
|Translated title of the contribution||The role of gelatinases and gelatinase inhibitors in gestational trophoblastic diseases and the normal placenta|
|Number of pages||5|
|Journal||Magyar Noorvosok Lapja|
|Publication status||Published - Jan 1 2002|
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology