A zselatinázok és a zselatináz inhibitorok szerepe a terhességi trofoblaszt betegségekben és a normál lepényben

Translated title of the contribution: The role of gelatinases and gelatinase inhibitors in gestational trophoblastic diseases and the normal placenta

György Végh, Selcuk Z. Tuncer, Imre Cseh, Samuel C. Mok, Ross S. Berkowitz, Piroska Páldi-Haris, János Földi, József Doszpod, V. Fülöp

Research output: Contribution to journalArticle

Abstract

Paraffin sections of 16 cases of partial mole, 25 cases of complet mole, 10 cases of gestational choriocarcinoma, and 11 cases of first-trimester placenta were studied immunohistochemically for gelatinases (MMP-2, MMP-9) and its inhibitor (TIMP-1) expression, furthermore the role of these enzymes were investigated in the induction of persistent gestational trophoblastic diseases. MMP-2 was expressed only in syncytio- and extravillous trophoblasts in normal placenta, partial mole and complet mole. Chorio-carcinoma and the extravillous trophoblast in partial mole and complet mole had significantly stronger staining for MMP-2 than the extravillous trophoblast in placenta (P=0,04, P

Original languageHungarian
Pages (from-to)155-159
Number of pages5
JournalMagyar Noorvosok Lapja
Volume65
Issue number3
Publication statusPublished - 2002

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Gestational Trophoblastic Disease
Gelatinases
Matrix Metalloproteinase Inhibitors
Matrix Metalloproteinases
Placenta
Trophoblasts
Choriocarcinoma
Tissue Inhibitor of Metalloproteinase-1
First Pregnancy Trimester
Paraffin
Staining and Labeling
Carcinoma
Enzymes

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Végh, G., Tuncer, S. Z., Cseh, I., Mok, S. C., Berkowitz, R. S., Páldi-Haris, P., ... Fülöp, V. (2002). A zselatinázok és a zselatináz inhibitorok szerepe a terhességi trofoblaszt betegségekben és a normál lepényben. Magyar Noorvosok Lapja, 65(3), 155-159.

A zselatinázok és a zselatináz inhibitorok szerepe a terhességi trofoblaszt betegségekben és a normál lepényben. / Végh, György; Tuncer, Selcuk Z.; Cseh, Imre; Mok, Samuel C.; Berkowitz, Ross S.; Páldi-Haris, Piroska; Földi, János; Doszpod, József; Fülöp, V.

In: Magyar Noorvosok Lapja, Vol. 65, No. 3, 2002, p. 155-159.

Research output: Contribution to journalArticle

Végh, G, Tuncer, SZ, Cseh, I, Mok, SC, Berkowitz, RS, Páldi-Haris, P, Földi, J, Doszpod, J & Fülöp, V 2002, 'A zselatinázok és a zselatináz inhibitorok szerepe a terhességi trofoblaszt betegségekben és a normál lepényben', Magyar Noorvosok Lapja, vol. 65, no. 3, pp. 155-159.
Végh G, Tuncer SZ, Cseh I, Mok SC, Berkowitz RS, Páldi-Haris P et al. A zselatinázok és a zselatináz inhibitorok szerepe a terhességi trofoblaszt betegségekben és a normál lepényben. Magyar Noorvosok Lapja. 2002;65(3):155-159.
Végh, György ; Tuncer, Selcuk Z. ; Cseh, Imre ; Mok, Samuel C. ; Berkowitz, Ross S. ; Páldi-Haris, Piroska ; Földi, János ; Doszpod, József ; Fülöp, V. / A zselatinázok és a zselatináz inhibitorok szerepe a terhességi trofoblaszt betegségekben és a normál lepényben. In: Magyar Noorvosok Lapja. 2002 ; Vol. 65, No. 3. pp. 155-159.
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AB - Paraffin sections of 16 cases of partial mole, 25 cases of complet mole, 10 cases of gestational choriocarcinoma, and 11 cases of first-trimester placenta were studied immunohistochemically for gelatinases (MMP-2, MMP-9) and its inhibitor (TIMP-1) expression, furthermore the role of these enzymes were investigated in the induction of persistent gestational trophoblastic diseases. MMP-2 was expressed only in syncytio- and extravillous trophoblasts in normal placenta, partial mole and complet mole. Chorio-carcinoma and the extravillous trophoblast in partial mole and complet mole had significantly stronger staining for MMP-2 than the extravillous trophoblast in placenta (P=0,04, P

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