The role of free radicals in endogenous adaptation and intracellular signals

E. Röth, L. Hejjel, M. T. Jaberansari, G. Jancso

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Oxidative stress can generate a mass of oxygen free radicals (OFR) in the cells, and these OFRs can induce several acute and chronic symptoms and diseases. If the amount of the generated OFRs overwhelms the antioxidant capacity of the cells, the pathophysiological changes may lead to the death of the cell or the development of chronic degenerative diseases. The phenomenon of ischemic preconditioning has demonstrated the important role of these aggressive and harmful molecules in the endogenous adaptation mechanism of the cells to oxidative stress. After sublethal oxidative stress - mild ischemic insult - the resulting development of a few OFRs can stimulate the intracellular signal-transduction cascade of ischemic preconditioning and, through the induction of severe transcription factors, new antioxidant enzymes and heat shock proteins will be synthesized. These newly synthesized proteins will protect the cellagainst another, more serious oxidative insult in the future.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalExperimental and Clinical Cardiology
Volume9
Issue number1
Publication statusPublished - Jun 24 2004

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Keywords

  • Endogenous adaptation
  • Free radicals
  • Ischemic preconditioning
  • Signal transduction

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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