The role of ficolins and MASPs in hereditary angioedema due to C1-inhibitor deficiency

Dorottya Csuka, Lea Munthe-Fog, Mikkel Ole Skjoedt, Andrea Kocsis, Zsuzsanna Zotter, P. Gál, L. Varga, H. Farkas, G. Füst, Peter Garred

Research output: Contribution to journalArticle

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Abstract

Background and Objective: Hereditary angioedema due to C1-inhibitor deficiency (HAE-C1-INH) causes disturbances in the complement system. However, the influence of HAE-C1-INH on the lectin pathway of complement is unresolved. Thus, we studied the main initiator molecules, enzymes and regulators in the lectin pathway in patients with HAE-C1-INH. Methods: The serum concentrations of ficolin-2, ficolin-3, MBL, MASP-2, MASP-3, and MAP-1 were measured during symptom-free periods in 91 patients with HAE-C1-INH, and in 100 healthy controls using sandwich ELISAs. Results: Compared with controls, the levels of ficolin-2 (p

Original languageEnglish
Pages (from-to)271-277
Number of pages7
JournalMolecular Immunology
Volume54
Issue number3-4
DOIs
Publication statusPublished - Jul 2013

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Mannose-Binding Protein-Associated Serine Proteases
Hereditary Angioedemas
Mannose-Binding Lectin Complement Pathway
ficolin
Lectins
Enzyme-Linked Immunosorbent Assay

Keywords

  • C1-inhibitor
  • Ficolin
  • Hereditary angioedema
  • Lectin pathway
  • MASP

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

Cite this

Csuka, D., Munthe-Fog, L., Skjoedt, M. O., Kocsis, A., Zotter, Z., Gál, P., ... Garred, P. (2013). The role of ficolins and MASPs in hereditary angioedema due to C1-inhibitor deficiency. Molecular Immunology, 54(3-4), 271-277. https://doi.org/10.1016/j.molimm.2012.12.015

The role of ficolins and MASPs in hereditary angioedema due to C1-inhibitor deficiency. / Csuka, Dorottya; Munthe-Fog, Lea; Skjoedt, Mikkel Ole; Kocsis, Andrea; Zotter, Zsuzsanna; Gál, P.; Varga, L.; Farkas, H.; Füst, G.; Garred, Peter.

In: Molecular Immunology, Vol. 54, No. 3-4, 07.2013, p. 271-277.

Research output: Contribution to journalArticle

Csuka, Dorottya ; Munthe-Fog, Lea ; Skjoedt, Mikkel Ole ; Kocsis, Andrea ; Zotter, Zsuzsanna ; Gál, P. ; Varga, L. ; Farkas, H. ; Füst, G. ; Garred, Peter. / The role of ficolins and MASPs in hereditary angioedema due to C1-inhibitor deficiency. In: Molecular Immunology. 2013 ; Vol. 54, No. 3-4. pp. 271-277.
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