The role of endothelin-B receptors in myocardial and endothelial reperfusion injury after heart transplantation

G. Szabó, S. Böhrle, L. Fazekas, C. F. Vahl, S. Hagl

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: This study was designed to investigate the effects of the selective endothelin-B (ET-B) receptor agonist IRL1620 and the selective ET-B receptor antagonist BQ788 on myocardial and endothelial function after reversible deep hypothermic ischemia and reperfusion. Methods: Isogenic intraabdominal heterotopic heart transplantation was performed on Lewis rats. After one hour of cold ischemic preservation, reperfusion was started either after application of saline vehicle or IRL1620 or BQ788 or both. Left ventricular pressure-volume relations and myocardial blood flow were assessed after one and 24 hours of reperfusion. Endothelium-dependent vasodilatation to acetylcholine (ACH) and endothelium-independent vasodilatation to sodium nitroprusside (SNP) were also determined. Results: IRL1620 attenuated and BQ788 improved myocardial contractility significantly as indicated by the left or upward shift of the systolic pressure-volume relation, respectively, and significantly changed myocardial blood flow during early reperfusion (p

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalThoracic and Cardiovascular Surgeon
Volume49
Issue number3
DOIs
Publication statusPublished - 2001

Fingerprint

Endothelin B Receptors
Myocardial Reperfusion Injury
Heart Transplantation
Reperfusion
Vasodilation
Endothelium
Heterotopic Transplantation
Nitroprusside
Ventricular Pressure
Acetylcholine
Ischemia
Blood Pressure
BQ 788

Keywords

  • Contractile function
  • Endothelial function
  • Endothelin-antagonist
  • Heart transplantation
  • Reperfusion
  • Rheology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The role of endothelin-B receptors in myocardial and endothelial reperfusion injury after heart transplantation. / Szabó, G.; Böhrle, S.; Fazekas, L.; Vahl, C. F.; Hagl, S.

In: Thoracic and Cardiovascular Surgeon, Vol. 49, No. 3, 2001, p. 167-171.

Research output: Contribution to journalArticle

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AU - Vahl, C. F.

AU - Hagl, S.

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