In 8 anencephalic foetuses diagnosed by ultrasonic and x-ray examination, the authors determined the cortisol concentration of the amniotic fluid before and after intramuscular prednisolone treatment, as well as the ratio of lecithin to sphingomyelin (L/S). Compared with the data obtained in 122 normal newborns who had been born during the same pregnancy week, both the cortisol concentration and the L/S ratio was found to be significantly lower in all anencephalic foetuses. The authors found that with the anencephalic foetuses, foetal pulmonary maturity is retarded compared to the normal foetuses; antenatal treatment with glycocorticoid did not accelerate functional maturity of the foetal lung. The authors are of the opinion that an indispensable prerequisite of foetal pulmonary maturity and efficacy of the antenatal glycocorticoid treatment is an intact hypothalamic-hypophyseal adrenocortical system of the foetus.
|Number of pages||3|
|Journal||Zeitschrift fur Geburtshilfe und Perinatologie|
|Publication status||Published - Dec 1 1980|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Obstetrics and Gynaecology