The role of endocytic pathways in TGF-β signaling

P. Balogh, S. Katz, A. Kiss

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Transforming growth factor β (TGF-β) superfamily consists of numerous cytokins that regulate various cellular processes. TGF-β, the prototype of the family, signals through its cell surface serine/threonin kinase receptors and besides its role in cell differentiation, migration, adhesion etc. it is also able to induce epithelial-mesenchymal (EMT) transition via both Smad- pathway and MAPK- pathway. Among the different types of epithelial-mesenchymal transition, type II that is described to be associated with wound healing, tissue regeneration, organ fibrosis and is induced upon inflammatory stimuli. It can be triggered by secretion of growth factors such as TGF-β, EGF. Different endocytic routes are used for the internalization of TGF-β ligand and its receptors and these pathways can control the activity of downstream events. Internalization via clathrin-coated vesicles promotes the signaling while the caveola-mediated endocytosis plays important role in the termination of the events, although the steps of the latter event are less clear. The early endosome is considered a clue compartment in promoting the signaling. Recently published data suggest that the early endosome plays crucial role in the termination of the TGFβ signaling as well. It is not only maintain a special environment for the effective signaling but can direct the internalized cargos towards degradative pathways (multivesicular bodies, lysosomes).

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalPathology and Oncology Research
Volume19
Issue number2
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Transforming Growth Factors
Epithelial-Mesenchymal Transition
Endosomes
Clathrin-Coated Vesicles
Multivesicular Bodies
Caveolae
Protein-Serine-Threonine Kinases
Endocytosis
Lysosomes
Epidermal Growth Factor
Wound Healing
Cell Movement
Regeneration
Cell Differentiation
Intercellular Signaling Peptides and Proteins
Fibrosis
Ligands

Keywords

  • Caveolae
  • Early endosome
  • EMT
  • Endocytosis
  • TGF-β

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

The role of endocytic pathways in TGF-β signaling. / Balogh, P.; Katz, S.; Kiss, A.

In: Pathology and Oncology Research, Vol. 19, No. 2, 04.2013, p. 141-148.

Research output: Contribution to journalArticle

Balogh, P. ; Katz, S. ; Kiss, A. / The role of endocytic pathways in TGF-β signaling. In: Pathology and Oncology Research. 2013 ; Vol. 19, No. 2. pp. 141-148.
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