The role of endocannabinoids in the regulation of luteinizing hormone and prolactin release. Differences between the effects of AEA and 2AG

Márk Oláh, Hadar Milloh, T. Wenger

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

It has been shown that the endocannabinoids inhibit luteinizing hormone (LH) and prolactin (PRL) secretion. When the effects of the two well-known endocannabinoids arachidonoylethanolamide (AEA, anandamide) and 2-arachidonoyl-glycerol (2AG) have been compared it became evident that AEA caused inhibition was higher than that one of 2AG. AEA also diminished the two investigated hormonal levels in CB1 receptor inactivated mice. AEA, being an endogenous ligand of vanilloid type 1 (TPRV1) receptor, while activating TPRV1 receptor has an effect on both LH and PRL levels decrease because these later were abolished when capsazepin, antagonist of TPRV1 receptor was previously administered to the CB1 KO animals. We postulate that the difference between the effects of AEA and 2AG on the serum levels of LH and PRL is due to the difference in receptor activation of these two compounds, namely AEA can activate both CB1 and TRPV1 receptor but 2AG acts only on CB1 receptor.

Original languageEnglish
JournalMolecular and Cellular Endocrinology
Volume286
Issue number1-2 SUPPL. 1
DOIs
Publication statusPublished - Apr 16 2008

Fingerprint

Endocannabinoids
Luteinizing Hormone
Cannabinoid Receptor CB1
Prolactin
Animals
Chemical activation
Ligands
2-arachidonylglycerol
Serum
anandamide

Keywords

  • CB KO mouse
  • Endocannabinoids
  • Luteinizing hormone
  • Prolactin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

The role of endocannabinoids in the regulation of luteinizing hormone and prolactin release. Differences between the effects of AEA and 2AG. / Oláh, Márk; Milloh, Hadar; Wenger, T.

In: Molecular and Cellular Endocrinology, Vol. 286, No. 1-2 SUPPL. 1, 16.04.2008.

Research output: Contribution to journalArticle

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